Overview

  • Product name

    Anti-SLC34A2 antibody - C-terminal
    See all SLC34A2 primary antibodies
  • Description

    Rabbit polyclonal to SLC34A2 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human SLC34A2 (C terminal). NP_001171469.
    Database link: O95436-2

  • Positive control

    • Human breast cancer and ovarian cancer tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab198735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/300.

Target

  • Function

    May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
  • Tissue specificity

    Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
  • Involvement in disease

    Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM) [MIM:265100]. Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.
  • Sequence similarities

    Belongs to the SLC34A transporter family.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Na(+)-dependent phosphate cotransporter 2B antibody
    • Na(+)/Pi cotransporter 2B antibody
    • NaPi-2b antibody
    • NaPi3b antibody
    • NPT2B_HUMAN antibody
    • SLC34A2 antibody
    • Sodium-dependent phosphate transport protein 2B antibody
    • Sodium-phosphate transport protein 2B antibody
    • Sodium/phosphate cotransporter 2B antibody
    • Solute carrier family 34 member 2 antibody
    see all

Images

  • Immunohistochemical analysis of Paraffin-embedded Human ovarian cancer tissue labeling SLC34A2 with ab198735 at 1/70 dilution.

  • Immunohistochemical analysis of Paraffin-embedded Human breast cancer tissue labeling SLC34A2 with ab198735 at 1/70 dilution.

References

ab198735 has not yet been referenced specifically in any publications.

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