Overview

  • Product name

  • Description

    Goat polyclonal to SLC40A1
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide corresponding to Human SLC40A1 aa 245-259 (internal sequence) (Cysteine residue). Accession Number: NP_055400.1
    Sequence:

    ELKQLNLHKDTEPKP


    Database link: Q9NP59

  • Positive control

    • Human breast cancer lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab205376 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab205376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 63 kDa).

Target

  • Function

    May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
  • Tissue specificity

    Expressed in placenta, intestine, muscle and spleen.
  • Involvement in disease

    Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation.
  • Sequence similarities

    Belongs to the SLC40A transporter family.
  • Cellular localization

    Cell membrane. Localized to the basolateral membrane of polarized epithelial cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ferroportin 1 antibody
    • Ferroportin antibody
    • Ferroportin-1 antibody
    • FPN1 antibody
    • HFE4 antibody
    • IREG1 antibody
    • iron regulated gene 1 antibody
    • Iron regulated transporter 1 antibody
    • Iron-regulated transporter 1 antibody
    • MST079 antibody
    • MSTP079 antibody
    • MTP1 antibody
    • putative ferroportin 1 variant IIIA antibody
    • putative ferroportin 1 variant IIIB antibody
    • S40A1_HUMAN antibody
    • SLC11A3 antibody
    • SLC11A3, formerly antibody
    • SLC40A1 antibody
    • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 antibody
    • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, formerly antibody
    • solute carrier family 40 (iron-regulated transporter), member 1 antibody
    • Solute carrier family 40 member 1 antibody
    see all

Images

  • Anti-SLC40A1 antibody (ab205376) at 1 µg/ml + Human breast cancer lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 63 kDa
    Observed band size: 55 kDa
    why is the actual band size different from the predicted?

References

ab205376 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab205376.
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