Overview

  • Product name

    Anti-SLC40A1 antibody [C8]
    See all SLC40A1 primary antibodies
  • Description

    Mouse monoclonal [C8] to SLC40A1
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment corresponding to Human SLC40A1 aa 127-321. N-terminal His and GST tag. Expressed in E. coli. Trp127~Val321 linked with LEHHHHHH.
    Sequence:

    WVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNAT IRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKV YQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHEL EHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTV


    Database link: Q9NP59

  • Positive control

    • WB: Recombinant human SLC40A1 protein; Rat placenta tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab239511 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 5 µg/ml.

Target

  • Function

    May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
  • Tissue specificity

    Expressed in placenta, intestine, muscle and spleen.
  • Involvement in disease

    Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation.
  • Sequence similarities

    Belongs to the SLC40A transporter family.
  • Cellular localization

    Cell membrane. Localized to the basolateral membrane of polarized epithelial cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ferroportin 1 antibody
    • Ferroportin antibody
    • Ferroportin-1 antibody
    • FPN1 antibody
    • HFE4 antibody
    • IREG1 antibody
    • iron regulated gene 1 antibody
    • Iron regulated transporter 1 antibody
    • Iron-regulated transporter 1 antibody
    • MST079 antibody
    • MSTP079 antibody
    • MTP1 antibody
    • putative ferroportin 1 variant IIIA antibody
    • putative ferroportin 1 variant IIIB antibody
    • S40A1_HUMAN antibody
    • SLC11A3 antibody
    • SLC11A3, formerly antibody
    • SLC40A1 antibody
    • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 antibody
    • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, formerly antibody
    • solute carrier family 40 (iron-regulated transporter), member 1 antibody
    • Solute carrier family 40 member 1 antibody
    see all

Images

  • Anti-SLC40A1 antibody [C8] (ab239511) at 5 µg/ml + Recombinant human SLC40A1 protein
  • Anti-SLC40A1 antibody [C8] (ab239511) at 2 µg/ml + Rat placenta tissue lysate

    Secondary
    HRP-Goat Anti-Mouse IgG at 0.2 µg/ml

References

ab239511 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab239511.
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