• Product name
  • Description
    Rabbit polyclonal to SLC4A4/NBC
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide corresponding to Rat SLC4A4/NBC (C terminal). Synthetic peptide derived from the C-terminus of rat renal splice variant.

  • General notes

    Protein previously labeled as SLC4A4.



Our Abpromise guarantee covers the use of ab30322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-Fr: Use at an assay dependent dilution. (see refeences below: Schmitt BM et al. Immunolocalization of the electrogenic Na+-HCO-3 cotransporter in mammalian and amphibian kidney. Jensen LJ et al. Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis. Marino CR et al. Expression and distribution of the Na(+)-HCO(-)(3) cotransporter in human pancreas. Romero MF et al. Cloning and functional expression of rNBC, an electrogenic Na(+)-HCO3- cotransporter from rat kidney.

    WB: 1/500 - 1/2500. Predicted molecular weight: 120 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
    • Tissue specificity
      Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.
    • Involvement in disease
      Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA) [MIM:604278]; also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy.
      Note=Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17).
    • Sequence similarities
      Belongs to the anion exchanger (TC 2.A.31) family.
    • Post-translational
      Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylation of Thr-49 regulates isoform 1 conductance.
      N-glycosylation is not necessary for the transporter basic functions.
    • Cellular localization
      Basolateral cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp781H1314 antibody
      • Electrogenic sodium bicarbonate cotransporter 1 antibody
      • hhNMC antibody
      • HNBC 1 antibody
      • HNBC1 antibody
      • kNBC 1 antibody
      • KNBC antibody
      • kNBC1 antibody
      • Na(+)/HCO3(-) cotransporter antibody
      • Na+HCO3- cotransporter 4 antibody
      • NBC 1 antibody
      • NBC 2 antibody
      • NBC1 antibody
      • NBC2 antibody
      • Nbc4 antibody
      • NBCE 1 antibody
      • NBCE1 antibody
      • OTTHUMP00000160355 antibody
      • OTTHUMP00000218884 antibody
      • OTTHUMP00000218885 antibody
      • PNBC antibody
      • S4A4_HUMAN antibody
      • SLC4A4 antibody
      • SLC4A5 antibody
      • Sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas) antibody
      • Sodium bicarbonate cotransporter antibody
      • Sodium bicarbonate cotransporter kidney antibody
      • sodium bicarbonate cotransporter member 4 antibody
      • Sodium bicarbonate cotransporter pancreas antibody
      • Solute carrier family 4 member 4 antibody
      • Solute carrier family 4 sodium bicarbonate cotransporter member 4 antibody
      • Solute carrier family 4 sodium bicarbonate cotransporter member 5 antibody
      • Solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type antibody
      see all


    This product has been referenced in:
    • Yin J  et al. Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. Cell Mol Gastroenterol Hepatol 5:591-609 (2018). Read more (PubMed: 29930980) »
    • Chinigarzadeh A  et al. Genistein induces increase in fluid pH, Na+ and HCO3(-) concentration, SLC26A6 and SLC4A4 (NBCe1)-B expression in the uteri of ovariectomized rats. Int J Mol Sci 15:958-76 (2014). Read more (PubMed: 24434640) »
    See all 2 Publications for this product

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