Overview

  • Product name

    Anti-SLC4A5 antibody
  • Description

    Rabbit polyclonal to SLC4A5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human SLC4A5 aa 1071-1137.
    Database link: Q9BY07

  • Positive control

    • ICC/IF: HepG2 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab237042 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.

Target

  • Function

    Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
  • Tissue specificity

    Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.
  • Sequence similarities

    Belongs to the anion exchanger (TC 2.A.31) family.
  • Cellular localization

    Apical cell membrane. Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.
  • Information by UniProt
  • Database links

  • Alternative names

    • Electrogenic sodium bicarbonate cotransporter 4 antibody
    • MGC129662 antibody
    • NBC4 antibody
    • NBCe2 antibody
    • S4A5_HUMAN antibody
    • SLC4A5 antibody
    • Solute carrier family 4 member 5 antibody
    • Solute carrier family 4 sodium bicarbonate cotransporter member 5 antibody
    see all

Images

  • 4% formaldehyde-fixed, 0.2% Triton X-100 permeabilized HepG2 (human liver hepatocellular carcinoma cell line) cells stained for SLC4A5 (green) using ab237042 at 1/133 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L). Counter-stained with DAPI. Blocked in 10% normal Goat Serum.

References

ab237042 has not yet been referenced specifically in any publications.

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