Anti-SLC4A8/NBC antibody (ab125910)
Key features and details
- Rabbit polyclonal to SLC4A8/NBC
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-SLC4A8/NBC antibody -
Description
Rabbit polyclonal to SLC4A8/NBC -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment within Human SLC4A8/NBC aa 1-255. The exact sequence is proprietary.
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Positive control
- IMR32 and U87-MG whole cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab125910 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 117 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 117 kDa. |
Target
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Function
Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. -
Tissue specificity
Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. -
Sequence similarities
Belongs to the anion exchanger (TC 2.A.31) family. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 9498 Human
- Entrez Gene: 59033 Mouse
- Entrez Gene: 315311 Rat
- Omim: 605024 Human
- SwissProt: Q2Y0W8 Human
- SwissProt: Q8TC60 Human
- SwissProt: Q8JZR6 Mouse
- SwissProt: Q6RVG2 Rat
see all -
Alternative names
- Electroneutral Na(+)-driven Cl-HCO3 exchanger antibody
- Electroneutral sodium bicarbonate exchanger 1 antibody
- k-NBC3 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab125910 has not yet been referenced specifically in any publications.