Overview

  • Product name

  • Description

    Rabbit polyclonal to SLC7A9
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Flow Cyt, IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SLC7A9 aa 51-60 conjugated to Keyhole Limpet Haemocyanin (KLH).
    Sequence:

    SPKSVLSNTE


    Database link: P82251

  • Positive control

    • Rat kidney tissue; Mouse intestine lysate and Rat intestine tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab203385 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/20 - 1/100.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

When using a fluorescent probe the recommended dilution is 1/50 – 1/200

WB 1/100 - 1/1000. Predicted molecular weight: 53 kDa.

Target

  • Relevance

    SLC7A9 belongs to the amino acid-polyamine-organocation (APC) superfamily. It is a disulfide linked heterodimer with the amino acid transport protein SLC3A1. SLC7A9 is involved in the high affinity, sodium independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high affinity reabsorption of cystine in the kidney tubule. Defects in SLC7A9 are a cause of non type I cystinuria (CSNU). CSNU arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described: type I (fully recessive or silent); type II (high excretor); type III (moderate excretor). Defects in SLC7A9 are associated with type II and type III cystinuria. They also might account for some non classic type I cystinuria cases.
  • Cellular localization

    Membrane; multi pass membrane protein (probable)
  • Database links

  • Alternative names

    • B(0+) type amino acid transporter 1 antibody
    • BAT1 antibody
    • CSNU3 antibody
    • Glycoprotein associated amino acid transporter b0+AT1 antibody
    • Solute carrier family 7 (cationic amino acid transporter y+ system) member 9 antibody
    see all

Images

  • Anti-SLC7A9 antibody (ab203385) at 1/200 dilution + Mouse intestine cell lysate

    Predicted band size: 53 kDa



    12% SDS PAGE, incubated overnight at 4°C.

  • Immunohistochemical staining of Rat intestine tissue labeling SLC7A9 using ab203385 at 1/200 dilution, followed by secondary detection and DAB staining.

  • Immunohistochemical staining of Rat kidney tissue labeling SLC7A9 using ab203385 at 1/200 dilution, followed by secondary detection and DAB staining.

References

ab203385 has not yet been referenced specifically in any publications.

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