SLC8A3 is a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner.
Immunohistochemistry analysis of formalin fixed and paraffin embedded Human brain tissue labeling SLC8A3 with ab170763 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot - Anti-SLC8A3 antibody - C-terminal (ab170763)
Anti-SLC8A3 antibody - C-terminal (ab170763) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg