Anti-SLCO1B3/OATP1B3 antibody [CL3770] (ab242368)

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Overview

  • Product name

    Anti-SLCO1B3/OATP1B3 antibody [CL3770]
    See all SLCO1B3/OATP1B3 primary antibodies

  • Description

    Mouse monoclonal [CL3770] to SLCO1B3/OATP1B3

  • Host species

    Mouse

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant fragment corresponding to Human SLCO1B3/OATP1B3 aa 652-701.
    Sequence:

    QGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAA


    Database link: Q9NPD5

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • IHC-P: Human liver tissue.

  • General notes

     This product was previously labelled as SLCO1B3

     

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 40% Glycerol, PBS
  • Concentration information loading...

  • Purity

    Protein A purified

  • Purification notes

    Purified from TCS.

  • Clonality

    Monoclonal

  • Clone number

    CL3770

  • Isotype

    IgG1

Applications

Our Abpromise guarantee covers the use of ab242368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

  • Tissue specificity

    Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

  • Involvement in disease

    Hyperbilirubinemia, Rotor type

  • Sequence similarities

    Belongs to the organo anion transporter (TC 2.A.60) family.
    Contains 1 Kazal-like domain.

  • Post-translational
    modifications

    N-glycosylated.

  • Cellular localization

    Basolateral cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • HBLRR antibody
      • Liver-specific organic anion transporter 2 antibody
      • LST-2 antibody
      • LST-3TM13 antibody
      • LST3 antibody
      • OATP-8 antibody
      • OATP1B3 antibody
      • Organic anion transporter 8 antibody
      • Organic anion-transporting polypeptide 8 antibody
      • SLC21A8 antibody
      • SLCO1B3 antibody
      • SO1B3_HUMAN antibody
      • Solute carrier family 21 member 8 antibody
      • Solute carrier organic anion transporter family member 1B3 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLCO1B3/OATP1B3 antibody [CL3770] (ab242368)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLCO1B3/OATP1B3 antibody [CL3770] (ab242368)

      Formalin-fixed, paraffin-embedded human liver tissue stained for SLCO1B3/OATP1B3 with ab242368 at a 1:200 dilution in immunohistochemical analysis.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLCO1B3/OATP1B3 antibody [CL3770] (ab242368)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLCO1B3/OATP1B3 antibody [CL3770] (ab242368)

      Negative control - Formalin-fixed, paraffin-embedded human pancreas tissue stained for SLCO1B3/OATP1B3 with ab242368 at a 1:200 dilution in immunohistochemical analysis.

    References

    ab242368 has not yet been referenced specifically in any publications.

    Publishing research using ab242368? Please let us know so that we can cite the reference in this datasheet.

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