Anti-SLCO1B3/OATP1B3 antibody [CL3770] (ab242368)
Key features and details
- Mouse monoclonal [CL3770] to SLCO1B3/OATP1B3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-SLCO1B3/OATP1B3 antibody [CL3770]
See all SLCO1B3/OATP1B3 primary antibodies -
Description
Mouse monoclonal [CL3770] to SLCO1B3/OATP1B3 -
Host species
Mouse -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human SLCO1B3/OATP1B3 aa 650 to the C-terminus.
Database link: Q9NPD5 -
Positive control
- IHC-P: Human liver tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
Purified from TCS. -
Clonality
Monoclonal -
Clone number
CL3770 -
Isotype
IgG1
Associated products
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Compatible Secondaries
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab242368 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. -
Tissue specificity
Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder. -
Involvement in disease
Hyperbilirubinemia, Rotor type -
Sequence similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain. -
Post-translational
modificationsN-glycosylated. -
Cellular localization
Basolateral cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 28234 Human
- Omim: 605495 Human
- SwissProt: Q9NPD5 Human
- Unigene: 504966 Human
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Alternative names
- HBLRR antibody
- Liver-specific organic anion transporter 2 antibody
- LST-2 antibody
see all
Images
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Formalin-fixed, paraffin-embedded human liver tissue stained for SLCO1B3/OATP1B3 with ab242368 at a 1:200 dilution in immunohistochemical analysis.
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Negative control - Formalin-fixed, paraffin-embedded human pancreas tissue stained for SLCO1B3/OATP1B3 with ab242368 at a 1:200 dilution in immunohistochemical analysis.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab242368 has not yet been referenced specifically in any publications.