Overview

  • Product name

    Anti-Slingshot homolog 1/SSH1 antibody [6C11G9]
    See all Slingshot homolog 1/SSH1 primary antibodies
  • Description

    Mouse monoclonal [6C11G9] to Slingshot homolog 1/SSH1
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human Slingshot homolog 1/SSH1 aa 1032-1044. expressed in E. Coli.
    Sequence:

    SGKPAPENLKSPS


    Database link: Q8WYL5

  • Positive control

    • Human ovarian cancer tissue; HeLa cells.
  • General notes

     This product was previously labelled as Slingshot homolog 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab204945 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/1000.
Flow Cyt 1/200 - 1/400.

Target

  • Function

    Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications

    Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
  • Cellular localization

    Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cleavage furrow. Midbody. Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
  • Information by UniProt
  • Database links

  • Alternative names

    • AW551225 antibody
    • Coro1c antibody
    • coronin, actin binding protein 1C antibody
    • Gm1394 antibody
    • Gm1395 antibody
    • hSSH-1L antibody
    • mSSH 1L antibody
    • OTTMUSP00000031415 antibody
    • Protein phosphatase Slingshot homolog 1 antibody
    • Slingshot 1 antibody
    • slingshot 1L antibody
    • slingshot homolog 1 antibody
    • slingshot like 1 antibody
    • Slingshot1 antibody
    • SSH 1 antibody
    • SSH 1L antibody
    • SSH-1L antibody
    • SSH-like protein 1 antibody
    • Ssh1 antibody
    • SSH1_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue labeling Slingshot homolog 1/SSH1 with ab204945 at 1/200 with DAB staining.

  • Flow cytometric analysis of Hela cells labeling Slingshot homolog 1/SSH1 using ab204945 at 1/200 (green) and negative control (red).

References

ab204945 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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