Key features and details
- Rabbit polyclonal to Slitrk1
- Suitable for: WB, ICC/IF, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Slitrk1 antibody
See all Slitrk1 primary antibodies
DescriptionRabbit polyclonal to Slitrk1
SpecificityThis antibody is predicted to have no cross-reactivity to other Slitrk proteins.
Tested applicationsSuitable for: WB, ICC/IF, IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
A 16 amino acid peptide from near the carboxy terminus of human Slitrk1.
- Human brain tissue lysate
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab67238 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 78 kDa).|
|ICC/IF||Use a concentration of 20 µg/ml.|
|IHC-P||Use at an assay dependent concentration.|
RelevanceSlitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.
Cellular localizationMembrane; Single-pass type I membrane protein
- SLITRK1 antibody
- FLJ54428 antibody
- KIAA0918 antibody
Immunofluorescence of Slitrk1 in Human brain tissue with ab67238 at 20 ug/mL.
Immunohistochemistry of Slitrk1 in Human brain tissue with Slitrk1 antibody at 2.5 μg/mL.
Lane 1 : Anti-Slitrk1 antibody (ab67238) at 1 µg/ml
Lane 2 : Anti-Slitrk1 antibody (ab67238) at 2 µg/ml
All lanes : human brain tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 78 kDa
Observed band size: 88 and 60 kDa why is the actual band size different from the predicted?
ab67238 has not yet been referenced specifically in any publications.