Overview

  • Product name

  • Description

    Rabbit polyclonal to Slitrk1
  • Host species

    Rabbit
  • Specificity

    This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
  • Tested applications

    Suitable for: WB, ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 16 amino acid peptide from near the carboxy terminus of human Slitrk1.

  • Positive control

    • Human brain tissue lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab67238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 78 kDa).
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use at an assay dependent concentration.

Target

  • Relevance

    Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.
  • Cellular localization

    Membrane; Single-pass type I membrane protein
  • Database links

  • Alternative names

    • SLITRK1 antibody
    • FLJ54428 antibody
    • KIAA0918 antibody
    • KIAA1910 antibody
    • Leucine rich repeat containing protein 12 antibody
    • LRRC1 antibody
    • LRRC12 antibody
    • RP11-395N17.1 antibody
    • SLIT and NTRK like family, member 1 antibody
    • SLIT and NTRK-like protein 1 antibody
    • slit and trk like gene 1 antibody
    • SLITRK 1 antibody
    • TTM antibody
    • UNQ233/PRO266 antibody
    see all

Images

  • Immunofluorescence of Slitrk1 in Human brain tissue with ab67238 at 20 ug/mL.

  • Immunohistochemistry of Slitrk1 in Human brain tissue with Slitrk1 antibody at 2.5 μg/mL.

  • Lane 1 : Anti-Slitrk1 antibody (ab67238) at 1 µg/ml
    Lane 2 : Anti-Slitrk1 antibody (ab67238) at 2 µg/ml

    All lanes : human brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 78 kDa
    Observed band size: 88 and 60 kDa
    why is the actual band size different from the predicted?

References

ab67238 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab67238.
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