Anti-Slitrk1 antibody (ab67238)
Key features and details
- Rabbit polyclonal to Slitrk1
- Suitable for: WB, ICC/IF, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Slitrk1 antibody -
Description
Rabbit polyclonal to Slitrk1 -
Host species
Rabbit -
Specificity
This antibody is predicted to have no cross-reactivity to other Slitrk proteins. -
Tested applications
Suitable for: WB, ICC/IF, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
A 16 amino acid peptide from near the carboxy terminus of human Slitrk1.
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Positive control
- Human brain tissue lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab67238 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 78 kDa).
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ICC/IF |
Use a concentration of 20 µg/ml.
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IHC-P |
Use at an assay dependent concentration.
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 78 kDa). |
ICC/IF
Use a concentration of 20 µg/ml. |
IHC-P
Use at an assay dependent concentration. |
Target
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Relevance
Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all. -
Cellular localization
Membrane; Single-pass type I membrane protein -
Database links
- Entrez Gene: 114798 Human
- Omim: 609678 Human
- SwissProt: Q96PX8 Human
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Alternative names
- SLITRK1 antibody
- FLJ54428 antibody
- KIAA0918 antibody
see all
Images
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Immunofluorescence of Slitrk1 in Human brain tissue with ab67238 at 20 ug/mL.
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Immunohistochemistry of Slitrk1 in Human brain tissue with Slitrk1 antibody at 2.5 μg/mL.
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Lane 1 : Anti-Slitrk1 antibody (ab67238) at 1 µg/ml
Lane 2 : Anti-Slitrk1 antibody (ab67238) at 2 µg/ml
All lanes : human brain tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 78 kDa
Observed band size: 60,88 kDa why is the actual band size different from the predicted?
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab67238 has not yet been referenced specifically in any publications.