Key features and details
- Rabbit polyclonal to SLITRK5
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-SLITRK5 antibody
See all SLITRK5 primary antibodies
DescriptionRabbit polyclonal to SLITRK5
Specificityab67309 is predicted to have no cross-reactivity to other SLITRK proteins.
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Mouse, Rat, Human
A 14 amino acid synthetic peptide from near the center of human SLITRK5.
- 3T3 cell lysate.
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab67309 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 160 kDa (predicted molecular weight: 107 kDa).|
|ICC/IF||Use a concentration of 20 µg/ml.|
RelevanceSLIT and NTRK-like family 5 (SLITRK5) is a member a protein family consisting of six homologous transmembrane proteins (SLITRK1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of SLITRK proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Like every other SLITRK protein except SLITRK1, overexpression of SLITRK5 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.
Cellular localizationMembrane; Single-pass type I membrane protein.
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All lanes : Anti-SLITRK5 antibody (ab67309) at 1 µg/ml
Lane 1 : 3T3 cell lysate with no blocking peptide
Lane 2 : 3T3 cell lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size: 107 kDa
Observed band size: 160 kDa why is the actual band size different from the predicted?
Immunofluorescence of SLITRK5 in Human Brain cells using ab67309 at 5 µg/ml.
ab67309 has been referenced in 1 publication.
- Kogan-Sakin I et al. Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ : (2010). PubMed: 20689556