Overview

  • Product name

    Anti-SLM-1 antibody [7G8C10] - C-terminal
  • Description

    Mouse monoclonal [7G8C10] to SLM-1 - C-terminal
  • Host species

    Mouse
  • Tested applications

    Suitable for: Flow Cyt, IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment corresponding to Human SLM-1 aa 160-349.
    Sequence:

    V PDYNDEIRQE QLRELSYLNG SEDSGRGRGI RGRGIRIAPT APSRGRGGAI PPPPPPGRGV LTPRGSTVTR GALPVPPVAR GVPTPRARGA PTVPGYRAPP PPAHEAYEEY GYDDGYGGEY DDQTYETYDN SYATQTQSVP EYYDYGHGVS EDAYDSYAPE EWATTRSSLK APPQRSARGG YREHPYGRY


    Database link: Q5VWX1

  • Positive control

    • Human SLM-1 (AA: 160-349) recombinant protein. K562, HEK293, NTERA-2, HeLa, HepG2, Jurkat, A431 and NIH/3T3 cell lysate. K562 cells. Human cervical cancer tissues. Human colon cancer tissues.
  • General notes

    Previously labelled as KHDRBS2. 

Properties

Applications

Our Abpromise guarantee covers the use of ab201982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/200 - 1/400.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

IHC-P 1/200 - 1/1000.
WB 1/500 - 1/2000. Predicted molecular weight: 39 kDa.

Target

  • Function

    RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability.
  • Tissue specificity

    Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.
  • Sequence similarities

    Belongs to the KHDRBS family.
    Contains 1 KH domain.
  • Post-translational
    modifications

    Methylated.
    Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • KH domain containing, RNA binding, signal transduction associated protein 2 antibody
    • 6330586C16Rik antibody
    • bA535F17.1 antibody
    • FLJ38664 antibody
    • hSLM 1 antibody
    • hSLM-1 antibody
    • KH domain containing, RNA binding, signal transduction associated 2 antibody
    • KH domain-containing antibody
    • KHDR2_HUMAN antibody
    • khdrbs2 antibody
    • MGC26664 antibody
    • RNA-binding antibody
    • Sam68 like mammalian protein 1 antibody
    • Sam68-like mammalian protein 1 antibody
    • signal transduction-associated protein 2 antibody
    • SLM 1 antibody
    • SLM-1 antibody
    • SLM1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded human colon cancer tissue labeling SLM-1 with ab201982 at 1/200 dilution with DAB staining.

  • Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue labeling SLM-1 with ab201982 at 1/200 dilution with DAB staining.

  • Flow cytometric analysis of K562 cells using ab201982 at 1/200 dilution (green) and negative control (red).

  • All lanes : Anti-SLM-1 antibody [7G8C10] - C-terminal (ab201982) at 1/500 dilution

    Lane 1 : K562 cell lysate
    Lane 2 : HEK293 cell lysate
    Lane 3 : NTERA-2 cell lysate
    Lane 4 : HeLa cell lysate
    Lane 5 : HepG2 cell lysate
    Lane 6 : Jurkat cell lysate
    Lane 7 : A431 cell lysate
    Lane 8 : NIH/3T3 cell lysate

    Predicted band size: 39 kDa

  • Anti-SLM-1 antibody [7G8C10] - C-terminal (ab201982) at 1/500 dilution + Human SLM-1 (AA: 160-349) recombinant protein

    Predicted band size: 39 kDa

References

ab201982 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab201982.
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