Key features and details
- Mouse monoclonal [IML-64] to Slow skeletal Myosin
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG1
Product nameAnti-Slow skeletal Myosin antibody [IML-64]
See all Slow skeletal Myosin primary antibodies
DescriptionMouse monoclonal [IML-64] to Slow skeletal Myosin
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Rat, Human
Human Slow skeletal Myosin purified from myofibrils.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.2
Preservative: 0.001% Sodium azide
Constituents: 1.2% Sodium acetate, 0.2% BSA
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab130179 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 22 kDa.|
FunctionRegulatory light chain of myosin. Does not bind calcium.
Involvement in diseaseDefects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
Sequence similaritiesContains 3 EF-hand domains.
modificationsThe N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.
- Information by UniProt
- Cardiac myosin light chain 1 antibody
- CMH8 antibody
- CMLC1 antibody
ab130179 has not yet been referenced specifically in any publications.