Overview

  • Product name

    Anti-Slow skeletal Myosin antibody [IML-64]
    See all Slow skeletal Myosin primary antibodies
  • Description

    Mouse monoclonal [IML-64] to Slow skeletal Myosin
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Human Slow skeletal Myosin purified from myofibrils.

Properties

Applications

Our Abpromise guarantee covers the use of ab130179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 22 kDa.
IHC-P Use a concentration of 1 - 2 µg/ml.

Target

  • Function

    Regulatory light chain of myosin. Does not bind calcium.
  • Involvement in disease

    Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
    Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
  • Sequence similarities

    Contains 3 EF-hand domains.
  • Post-translational
    modifications

    The N-terminus is blocked.
    N-terminus is methylated by METTL11A/NTM1.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cardiac myosin light chain 1 antibody
    • CMH8 antibody
    • CMLC1 antibody
    • MLC1SB antibody
    • MLC1V antibody
    • MYL3 antibody
    • MYL3_HUMAN antibody
    • Myosin light chain 1 antibody
    • Myosin light chain 1 slow twitch muscle B ventricular isoform antibody
    • myosin light chain 3 alkali ventricular skeletal slow antibody
    • Myosin light chain 3 antibody
    • slow-twitch muscle B/ventricular isoform antibody
    • Ventricular slow twitch myosin alkali light chain antibody
    • Ventricular/slow twitch myosin alkali light chain antibody
    • VLC1 antibody
    see all

Images

  • Anti-Slow skeletal Myosin antibody [IML-64] (ab130179) at 2 µg/ml + Slow skeletal muscle tissue lysate

    Predicted band size: 22 kDa

References

ab130179 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab130179.
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