Overview

  • Product name

    Anti-Slow Skeletal Myosin Heavy chain antibody - C-terminal
    See all Slow Skeletal Myosin Heavy chain primary antibodies
  • Description

    Rabbit polyclonal to Slow Skeletal Myosin Heavy chain - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Fusion protein within Human Slow Skeletal Myosin Heavy chain (C terminal). The exact sequence is proprietary. Fusion protein corresponding to residues near the C terminal of human Slow Skeletal Myosin Heavy chain. The identity of the protein fusion partner is GST.
    Database link: P12883

  • Positive control

    • Human colon cancer tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab197687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.

Target

  • Function

    Muscle contraction.
  • Tissue specificity

    Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level).
  • Involvement in disease

    Defects in MYH7 are the cause of cardiomyopathy familial hypertrophic type 1 (CMH1) [MIM:192600]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in MYH7 are the cause of myopathy myosin storage (MYOMS) [MIM:608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers.
    Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM) [MIM:181430]; also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm.
    Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S) [MIM:613426]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in MYH7 are the cause of myopathy distal type 1 (MPD1) [MIM:160500]. MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease.
  • Sequence similarities

    Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • Domain

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
  • Cellular localization

    Cytoplasm > myofibril. Thick filaments of the myofibrils.
  • Information by UniProt
  • Database links

  • Alternative names

    • Beta myosin heavy chain antibody
    • cardiac muscle beta isoform antibody
    • CMD1S antibody
    • CMH1 antibody
    • MPD1 antibody
    • MYH7 antibody
    • MYH7_HUMAN antibody
    • Myhc slow antibody
    • MyHC-beta antibody
    • MyHC-slow antibody
    • MYHCB antibody
    • Myopathy, distal 1 antibody
    • Myosin heavy chain (AA 1-96) antibody
    • Myosin heavy chain 7 antibody
    • Myosin heavy chain antibody
    • Myosin heavy chain slow isoform antibody
    • Myosin heavy chain, cardiac muscle beta isoform antibody
    • Myosin, heavy chain 7, cardiac muscle, beta antibody
    • Myosin, heavy polypeptide 7, cardiac muscle, beta antibody
    • Myosin-7 antibody
    • Rhabdomyosarcoma antigen MU RMS 40.7A antibody
    • SPMD antibody
    • SPMM antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling Slow Skeletal Myosin Heavy chain with ab197687 at 1/12.

References

ab197687 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab197687.
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