Anti-SLPI antibody - Aminoterminal end (ab46763)

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Key features and details

  • Rabbit polyclonal to SLPI - Aminoterminal end
  • Suitable for: WB
  • Reacts with: Human
  • Isotype: IgG

Overview

  • Product name

    Anti-SLPI antibody - Aminoterminal end
    See all SLPI primary antibodies

  • Description

    Rabbit polyclonal to SLPI - Aminoterminal end

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Synthetic peptide based on the aminoterminal end of human SLPI.(Please note: the amino acid sequence is proprietary) (Peptide available as ab46833.)

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Applications

Our Abpromise guarantee covers the use of ab46763 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 14 kDa.

A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Dilution optimised using Chromogenic detection.

Target

  • Function

    Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.

  • Tissue specificity

    Mucous fluids.

  • Sequence similarities

    Contains 2 WAP domains.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • ALK 1 antibody
      • ALK1 antibody
      • ALP antibody
      • Antileukoprotease antibody
      • Antileukoproteinase 1 antibody
      • Antileukoproteinase antibody
      • Antileukoproteinase1 antibody
      • BLPI antibody
      • Human seminal protease inhibitor antibody
      • HUSI 1 antibody
      • HUSI antibody
      • HUSI I antibody
      • HUSI-1 antibody
      • MPI antibody
      • Mucus proteinase inhibitor antibody
      • Protease inhibitor WAP4 antibody
      • Secretory leukocyte peptidase inhibitor antibody
      • Secretory leukocyte protease inhibitor antibody
      • Seminal proteinase inhibitor antibody
      • SLPI antibody
      • SLPI_HUMAN antibody
      • WAP four disulfide core domain protein 4 antibody
      • WAP four-disulfide core domain protein 4 antibody
      • WAP4 antibody
      • WFDC4 antibody
      see all

    Images

    • Western blot - Anti-SLPI antibody - Aminoterminal end (ab46763)
      Western blot - Anti-SLPI antibody - Aminoterminal end (ab46763)
      All lanes : Anti-SLPI antibody - Aminoterminal end (ab46763) at 1/1000 dilution

      Lane 1 : Recombinant Human SLP I at 0.04 µg
      Lane 2 : Recombinant Human SLP I at 0.02 µg
      Lane 3 : Recombinant Human SLP I at 0.01 µg
      Lane 4 : Recombinant Human SLP I at 0.004 µg
      Lane 5 : Recombinant Human SLP I at 0.001 µg

      Predicted band size: 14 kDa
      Observed band size: 15 kDa
      why is the actual band size different from the predicted?

    References (2)

    Publishing research using ab46763? Please let us know so that we can cite the reference in this datasheet.

    ab46763 has been referenced in 2 publications.

    • Klimenkova O  et al. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood 123:1239-49 (2014). Human . PubMed: 24352879
    • Yang Y  et al. Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker. PLoS One 9:e95389 (2014). WB ; Human . PubMed: 24748380

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