Overview

  • Product name
    Anti-SLPI antibody - Aminoterminal end
    See all SLPI primary antibodies
  • Description
    Rabbit polyclonal to SLPI - Aminoterminal end
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide based on the aminoterminal end of human SLPI.(Please note: the amino acid sequence is proprietary) (Peptide available as ab46833.)

Properties

Applications

Our Abpromise guarantee covers the use of ab46763 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 14 kDa.

A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Dilution optimised using Chromogenic detection.

Target

  • Function
    Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.
  • Tissue specificity
    Mucous fluids.
  • Sequence similarities
    Contains 2 WAP domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
    • Alternative names
      • ALK 1 antibody
      • ALK1 antibody
      • ALP antibody
      • Antileukoprotease antibody
      • Antileukoproteinase 1 antibody
      • Antileukoproteinase antibody
      • Antileukoproteinase1 antibody
      • BLPI antibody
      • Human seminal protease inhibitor antibody
      • HUSI 1 antibody
      • HUSI antibody
      • HUSI I antibody
      • HUSI-1 antibody
      • MPI antibody
      • Mucus proteinase inhibitor antibody
      • Protease inhibitor WAP4 antibody
      • Secretory leukocyte peptidase inhibitor antibody
      • Secretory leukocyte protease inhibitor antibody
      • Seminal proteinase inhibitor antibody
      • SLPI antibody
      • SLPI_HUMAN antibody
      • WAP four disulfide core domain protein 4 antibody
      • WAP four-disulfide core domain protein 4 antibody
      • WAP4 antibody
      • WFDC4 antibody
      see all

    Images

    • Western blot - Anti-SLPI antibody - Aminoterminal end (ab46763)
      Western blot - Anti-SLPI antibody - Aminoterminal end (ab46763)
      All lanes : Anti-SLPI antibody - Aminoterminal end (ab46763) at 1/1000 dilution

      Lane 1 : Recombinant Human SLP I at 0.04 µg
      Lane 2 : Recombinant Human SLP I at 0.02 µg
      Lane 3 : Recombinant Human SLP I at 0.01 µg
      Lane 4 : Recombinant Human SLP I at 0.004 µg
      Lane 5 : Recombinant Human SLP I at 0.001 µg

      Predicted band size: 14 kDa
      Observed band size: 15 kDa (why is the actual band size different from the predicted?)

    References

    This product has been referenced in:
    • Klimenkova O  et al. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood 123:1239-49 (2014). Human . Read more (PubMed: 24352879) »
    • Yang Y  et al. Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker. PLoS One 9:e95389 (2014). WB ; Human . Read more (PubMed: 24748380) »

    See all 2 Publications for this product

    Publishing research using ab46763? Please let us know so that we can cite the reference in this datasheet.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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