Overview

  • Product name

  • Description

    Rabbit polyclonal to SLUG
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog, Xenopus tropicalis
  • Immunogen

    Recombinant fragment within Human SLUG aa 120-268. The exact sequence is proprietary.
    Database link: O43623

  • Positive control

    • Human Slug-transfected 293T cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab183760 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 30 kDa.

Target

  • Function

    Transcriptional repressor. Involved in the generation and migration of neural crest cells.
  • Tissue specificity

    Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.
  • Involvement in disease

    Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.
  • Sequence similarities

    Belongs to the snail C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • MGC10182 antibody
    • Neural crest transcription factor Slug antibody
    • Protein snail homolog 2 antibody
    • Slug (chicken homolog) zinc finger protein antibody
    • Slug homolog zinc finger protein antibody
    • Slug zinc finger protein antibody
    • SLUGH antibody
    • SLUGH 1 antibody
    • SLUGH1 antibody
    • SNAI 2 antibody
    • Snai2 antibody
    • SNAI2_HUMAN antibody
    • Snail 2 antibody
    • Snail homolog 2 antibody
    • Snail2 antibody
    • WS 2D antibody
    • WS2D antibody
    • Zinc finger protein SLUG antibody
    • Zinc finger protein SNAI2 antibody
    see all

Images

  • All lanes : Anti-SLUG antibody (ab183760) at 1/5000 dilution

    Lane 1 : 293T whole cell lysate/extract
    Lane 2 : Whole cell lysate/extract of Human SLUG-transfected 293T cells

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 30 kDa

References

This product has been referenced in:

  • Su C  et al. MiR-21 improves invasion and migration of drug-resistant lung adenocarcinoma cancer cell and transformation of EMT through targeting HBP1. Cancer Med 7:2485-2503 (2018). WB ; Human . Read more (PubMed: 29663730) »
  • Cao Y  et al. LncRNA ATB promotes proliferation and metastasis in A549 cells by down-regulation of microRNA-494. J Cell Biochem 119:6935-6942 (2018). Read more (PubMed: 29693289) »
See all 2 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab183760.
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