Anti-SLUG antibody (ab27568)

Rabbit polyclonal SLUG antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Chicken. Cited in 58 publication(s). Independently reviewed in 11 review(s).

Publishing research using ab27568? Please let us know so that we can cite the reference in this datasheet.

ab27568 has been referenced in 62 publications.

  • Li L  et al. MiR-101-3p inhibits EMT to attenuate proliferation and metastasis in glioblastoma by targeting TRIM44. J Neurooncol 141:19-30 (2019). PubMed: 30539341
  • Feng S  et al. Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells. J Exp Clin Cancer Res 38:57 (2019). PubMed: 30728039
  • Flentke GR  et al. Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors. Birth Defects Res N/A:N/A (2019). PubMed: 31021056
  • Yin C  et al. miR-185-5p inhibits F-actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE. Mol Med Rep 18:2621-2630 (2018). PubMed: 30015912
  • Yan H  et al. Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis. J Exp Clin Cancer Res 37:237 (2018). PubMed: 30249278
  • Menezes SV  et al. The Metastasis Suppressor, NDRG1, Attenuates Oncogenic TGF-ß and NF-?B Signaling to Enhance Membrane E-Cadherin Expression in Pancreatic Cancer Cells. Carcinogenesis N/A:N/A (2018). PubMed: 30561520
  • Chen G  et al. Investigation of the role of cullin 4A overexpression in human liver cancer. Mol Med Rep 18:2531-2540 (2018). PubMed: 30015884
  • Qin SC  et al. Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion. Oncol Rep 40:1907-1916 (2018). PubMed: 30066897
  • Tao F  et al. The PCAT3/PCAT9-miR-203-SNAI2 axis functions as a key mediator for prostate tumor growth and progression. Oncotarget 9:12212-12225 (2018). PubMed: 29552304
  • Wang L  et al. TIPE-2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3-kinase/AKT signaling pathway. Mol Med Rep 17:7017-7026 (2018). PubMed: 29568863
  • Devis L  et al. ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer. Oncotarget 9:16648-16664 (2018). PubMed: 29682175
  • Han Q  et al. WWC3 inhibits epithelial-mesenchymal transition of lung cancer by activating Hippo-YAP signaling. Onco Targets Ther 11:2581-2591 (2018). PubMed: 29780251
  • Wu X  et al. Overexpression of MCPH1 inhibits the migration and invasion of lung cancer cells. Onco Targets Ther 11:3111-3117 (2018). PubMed: 29872322
  • Miscianinov V  et al. MicroRNA-148b Targets the TGF-ß Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing. Mol Ther N/A:N/A (2018). WB . PubMed: 29843955
  • Wang S  et al. Fibulin-3 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition and activating the Wnt/ß-catenin signaling pathway. Sci Rep 7:6215 (2017). WB . PubMed: 28740094
  • Zhang D  et al. Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway. Int J Oncol 50:1513-1530 (2017). WB ; Human . PubMed: 28339091
  • Li Z  et al. LncRNA ANCR down-regulation promotes TGF-ß-induced EMT and metastasis in breast cancer. Oncotarget 8:67329-67343 (2017). WB ; Human . PubMed: 28978036
  • Ju J  et al. NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression. Nat Commun 8:928 (2017). WB ; Human . PubMed: 29030587
  • Feng X  et al. Expression of EMT markers and mode of surgery are prognostic in phyllodes tumors of the breast. Oncotarget 8:33365-33374 (2017). IHC-P ; Human . PubMed: 28380418
  • Shi W  et al. MACC-1 antibody target therapy suppresses growth and migration of non-small cell lung cancer. Mol Med Rep 16:7329-7336 (2017). WB ; Human . PubMed: 28944826
  • Lv C  et al. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nat Commun 8:1036 (2017). IHC-P ; Mouse . PubMed: 29051494
  • Boldbaatar A  et al. Eupatolide inhibits the TGF-ß1-induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5. Oncol Lett 14:6031-6039 (2017). WB ; Human . PubMed: 29113242
  • Saxon JG  et al. BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling. Dev Biol 430:113-128 (2017). PubMed: 28790014
  • Wang C  et al. Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/ß-catenin signaling pathways in hepatocellular and colorectal carcinoma cells. Oncotarget 8:1092-1109 (2017). WB ; Human . PubMed: 27901475
  • Wang T  et al. Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/ß-catenin signaling pathway. Oncotarget 8:18991-19012 (2017). WB ; Human . PubMed: 28177909
  • Shen CJ  et al. MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer. PLoS One 12:e0174487 (2017). WB, ICC/IF ; Human . PubMed: 28334049
  • Zhang L  et al. Dysregulation of Fra1 expression by Wnt/ß-catenin signalling promotes glioma aggressiveness through epithelial-mesenchymal transition. Biosci Rep 37:N/A (2017). WB ; Human . PubMed: 28232512
  • Li X  et al. Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells. Sci Rep 7:5081 (2017). WB ; Human . PubMed: 28698547
  • Koga H  et al. Pancreatic DCLK1 marks quiescent but oncogenic progenitors: a possible link to neuroendocrine tumors. Stem Cell Investig 3:37 (2016). PubMed: 27668244
  • Imani S  et al. Prognostic Value of EMT-inducing Transcription Factors (EMT-TFs) in Metastatic Breast Cancer: A Systematic Review and Meta-analysis. Sci Rep 6:28587 (2016). PubMed: 27335258
  • Feng D  et al. Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis. Oncotarget 7:64575-64588 (2016). WB ; Human . PubMed: 27602489
  • Fang S  et al. Cisplatin promotes mesenchymal-like characteristics in osteosarcoma through Snail. Oncol Lett 12:5007-5014 (2016). WB . PubMed: 28105207
  • Gho CG  et al. Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery. Cytotechnology 68:1849-58 (2016). ICC/IF ; Human . PubMed: 26702932
  • Gao Y  et al. The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Sci Rep 6:19874 (2016). WB ; Human . PubMed: 26813495
  • Tong S  et al. 14-3-3? promotes lung cancer cell invasion by increasing the Snail protein expression through atypical protein kinase C (aPKC)/NF-?B signaling. Exp Cell Res 348:1-9 (2016). PubMed: 27554601
  • Tanaka N  et al. Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation. JCI Insight 1:e83654 (2016). PubMed: 27812537
  • Gu A  et al. Slug Is Associated With Tumor Metastasis and Angiogenesis in Ovarian Cancer. Reprod Sci N/A:N/A (2016). IHC ; Human . PubMed: 27368877
  • Xu X  et al. Snail Is a Direct Target of Hypoxia-inducible Factor 1a (HIF1a) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells. J Biol Chem 290:16653-64 (2015). PubMed: 25971970
  • Fisher ML  et al. Type II transglutaminase stimulates epidermal cancer stem cell epithelial-mesenchymal transition. Oncotarget 6:20525-39 (2015). Human . PubMed: 25971211
  • Zhao L  et al. Bufalin inhibits TGF-ß-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-ß receptors. Int J Mol Med : (2015). Human . PubMed: 26133118
  • Wen Z  et al. Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells. Int J Mol Med 36:1657-63 (2015). PubMed: 26497016
  • Gou WF  et al. The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells. BMC Cancer 14:477 (2014). WB ; Human . PubMed: 24986540
  • Weng W  et al. Metastasis-associated protein 1 promotes tumor invasion by downregulation of E-cadherin. Int J Oncol 44:812-8 (2014). Human . PubMed: 24424621
  • Kim MK  et al. Expression profiles of epithelial-mesenchymal transition-associated proteins in epithelial ovarian carcinoma. Biomed Res Int 2014:495754 (2014). IHC-P ; Human . PubMed: 24800235
  • Serrano MJ  et al. EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer. Oncotarget 5:7486-97 (2014). WB ; Human . PubMed: 25277187
  • König K  et al. Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS One 8:e57996 (2013). IHC-P ; Mouse . PubMed: 23536778
  • Knackstedt RW  et al. Vitamin D receptor and retinoid X receptor a status and vitamin D insufficiency in models of murine colitis. Cancer Prev Res (Phila) 6:585-93 (2013). PubMed: 23585425
  • Kumar M  et al. NF-?B regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells. PLoS One 8:e68597 (2013). PubMed: 23935876
  • Hugo HJ  et al. Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells. Breast Cancer Res 15:R113 (2013). Human . PubMed: 24283570
  • Chen YS  et al. Enhanced filopodium formation and stem-like phenotypes in a novel metastatic head and neck cancer cell model. Oncol Rep 30:2829-37 (2013). WB ; Human . PubMed: 24100418
  • van Nes JG  et al. Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients. Breast Cancer Res Treat 133:49-59 (2012). IHC . PubMed: 21796367
  • Lu ZY  et al. SNAI1 overexpression induces stemness and promotes ovarian cancer cell invasion and metastasis. Oncol Rep 27:1587-91 (2012). Human . PubMed: 22344746
  • Hance MW  et al. Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer. J Biol Chem 287:37732-44 (2012). WB . PubMed: 22989880
  • Kong C  et al. NEDD9 Is a Positive Regulator of Epithelial-Mesenchymal Transition and Promotes Invasion in Aggressive Breast Cancer. PLoS One 6:e22666 (2011). WB ; Human . PubMed: 21829474
  • Wushou A  et al. Correlation of Increased Twist With Lymph Node Metastasis in Patients With Oral Squamous Cell Carcinoma. J Oral Maxillofac Surg : (2011). IHC-P ; Human . PubMed: 21864967
  • Deep G  et al. Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells. Cancer Prev Res (Phila) 4:1222-32 (2011). WB ; Human . PubMed: 21546539
  • Tiang JM  et al. RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition. PLoS One 6:e17031 (2011). WB ; Human . PubMed: 21347396
  • Herfs M  et al. Regulation of p63 Isoforms by Snail and Slug Transcription Factors in Human Squamous Cell Carcinoma. Am J Pathol 176:1941-9 (2010). IHC-P, IHC-Fr ; Human . PubMed: 20150431
  • Medici D  et al. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 16:1400-6 (2010). ELISA . PubMed: 21102460
  • Bell CE & Watson AJ SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst. PLoS One 4:e8530 (2009). IHC-P ; Mouse . PubMed: 20046880
  • Massoumi R  et al. Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med 206:221-32 (2009). WB ; Human . PubMed: 19124656
  • Arnoux V  et al. Erk5 controls Slug expression and keratinocyte activation during wound healing. Mol Biol Cell 19:4738-49 (2008). WB, ICC/IF ; Human . PubMed: 18716062

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