Key features and details
- Rabbit polyclonal to SMAD6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SMAD6 antibody
See all SMAD6 primary antibodies
DescriptionRabbit polyclonal to SMAD6
SpecificityThis reacts specifically with human 54 kDa SMAD6 isoform D protein. It is not expected to cross react with other species.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide derived from the C terminal domain of SMAD6 Isoform D
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferConstituent: Whole serum
Concentration information loading...
Our Abpromise guarantee covers the use of ab80049 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/5000. Predicted molecular weight: 53 kDa.|
FunctionAntagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.
Tissue specificityUbiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Sequence similaritiesBelongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain.
modificationsPhosphorylated by BMP type 1 receptor kinase and by PRKX.
Ubiquitinated by WWP1.
- Information by UniProt
- hSMAD6 antibody
- MAD homolog 6 antibody
- MADH6 antibody
ab80049 has been referenced in 3 publications.
- Xu S & Wu X miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6. Biosci Rep 39:N/A (2019). PubMed: 30135141
- Park JS et al. RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31690042
- Piacentino ML & Bronner ME Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction. PLoS Biol 16:e2004425 (2018). PubMed: 29949573