Anti-SMAD9 antibody (ab48011)

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Western blot - Anti-SMAD9 antibody (ab48011)

    Key features and details

    • Goat polyclonal to SMAD9
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-SMAD9 antibody
      See all SMAD9 primary antibodies

    • Description

      Goat polyclonal to SMAD9

    • Host species

      Goat

    • Specificity

      Not expected to crossreact with SMAD1 or SMAD5.

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Chicken, Dog

    • Immunogen

      Synthetic peptide:

      C-HSEPLMPHNATYPD

      , corresponding to internal sequence amino acids 166-179 of Human SMAD9.
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • Positive control

      • Human skin lysate.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab48011 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa).

    1 hour primary incubation is recommended for this product.
    Notes
    WB
    Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa).

    1 hour primary incubation is recommended for this product.

    Target

    • Function

      Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

    • Tissue specificity

      Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.

    • Involvement in disease

      Pulmonary hypertension, primary, 2

    • Sequence similarities

      Belongs to the dwarfin/SMAD family.
      Contains 1 MH1 (MAD homology 1) domain.
      Contains 1 MH2 (MAD homology 2) domain.

    • Post-translational
      modifications

      Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.

    • Cellular localization

      Cytoplasm. Nucleus. In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • MAD homolog 9 antibody
      • Madh6 antibody
      • Mothers against decapentaplegic antibody
      • Mothers against decapentaplegic homolog 9 antibody
      • Mothers against DPP homolog 9 antibody
      • SMAD 9 antibody
      • SMAD family member 9 antibody
      • SMAD, mothers against DPP homolog 9 (Drosophila) antibody
      • SMAD8A antibody
      • SMAD8B antibody
      • Smad9 antibody
      • SMAD9_HUMAN antibody
      see all

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    References (0)

    Publishing research using ab48011? Please let us know so that we can cite the reference in this datasheet.

    ab48011 has not yet been referenced specifically in any publications.

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