Overview

  • Product name
    Anti-SMAD9 antibody
    See all SMAD9 primary antibodies
  • Description
    Goat polyclonal to SMAD9
  • Host species
    Goat
  • Specificity
    Not expected to crossreact with SMAD1 or SMAD5.
  • Tested applications
    Suitable for: Sandwich ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Dog
  • Immunogen

    Synthetic peptide:

    C-HSEPLMPHNATYPD

    , corresponding to internal sequence amino acids 166-179 of Human SMAD9.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Human skin lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab48011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use a concentration of 1 - 2 µg/ml. Used as a reporter to detect captured recombinant SMAD9
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa).

Target

  • Function
    Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
  • Tissue specificity
    Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
  • Involvement in disease
    Pulmonary hypertension, primary, 2
  • Sequence similarities
    Belongs to the dwarfin/SMAD family.
    Contains 1 MH1 (MAD homology 1) domain.
    Contains 1 MH2 (MAD homology 2) domain.
  • Post-translational
    modifications
    Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
  • Cellular localization
    Cytoplasm. Nucleus. In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • MAD homolog 9 antibody
    • Madh6 antibody
    • Mothers against decapentaplegic antibody
    • Mothers against decapentaplegic homolog 9 antibody
    • Mothers against DPP homolog 9 antibody
    • SMAD 9 antibody
    • SMAD family member 9 antibody
    • SMAD, mothers against DPP homolog 9 (Drosophila) antibody
    • SMAD8A antibody
    • SMAD8B antibody
    • Smad9 antibody
    • SMAD9_HUMAN antibody
    see all

Images

References

ab48011 has not yet been referenced specifically in any publications.

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