Overview

  • Product name

    SMER28, mammalian autophagy regulator
  • Description

    Positive mammalian autophagy regulator
  • Biological description

    Positive mammalian autophagy regulator. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as A53T α-synuclein.
  • Purity

    > 98%
  • CAS Number

    307538-42-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Bromo-N-prop-2-enylquinazolin-4-amine
  • Molecular weight

    264.12
  • Molecular formula

    C11H10BrN3
  • PubChem identifier

    1560402
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C=CCNC1=NC=NC2=C1C=C(C=C2)Br
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tian Y  et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J 25:1934-42 (2011). Read more (PubMed: 21368103) »
  • Sarkar S  et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 3:331-8 (2007). Read more (PubMed: 17486044) »

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