Overview

  • Product name

  • Description

    Rabbit polyclonal to SMG7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 719-1003 of Human SMG7, isoform 4 (AAH36381).

  • Positive control

    • NT2D1 whole cell lysate; HeLa xenograft tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin
    Constituents: PBS, 1% BSA, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 132 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function

    Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
  • Sequence similarities

    Contains 2 TPR repeats.
  • Cellular localization

    Cytoplasm. Nucleus. Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • breast cancer-associated antigen SGA-56M antibody
    • C1orf16 antibody
    • EST1 like protein C antibody
    • EST1 telomerase component homolog C antibody
    • EST1-like protein C antibody
    • EST1C antibody
    • ever shorter telomeres 1C antibody
    • FLJ23717 antibody
    • hSMG-7 antibody
    • nonsense mediated mRNA decay factor (C. elegans) antibody
    • Protein SMG7 antibody
    • SGA56M antibody
    • SMG 7 antibody
    • SMG-7 homolog antibody
    • Smg7 antibody
    • SMG7_HUMAN antibody
    see all

Images

  • Anti-SMG7 antibody (ab126984) at 1/1000 dilution + NT2D1 cell lysate at 30 µg

    Predicted band size: 132 kDa



    5% SDS PAGE
  • ab126984 at a 1/500 dilution staining SMG7 in paraffin-embedded HeLa xenograft tissue by Immunohistochemistry.

References

ab126984 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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