SMI-4a, ATP-competitive Pim kinase inhibitor (ab141367)

Overview

  • Product name

    SMI-4a, ATP-competitive Pim kinase inhibitor
  • Description

    Potent, selective, cell-permeable, ATP-competitive Pim kinase inhibitor
  • Alternative names

    • TCS PIM-1 4a
  • Biological description

    Potent, selective, cell-permeable, ATP-competitive Pim-1 kinase inhibitor (IC50 = 17 nM). Moderately potent against Pim-2 kinase. Selective versus a panel of other serine/threonine and tyrosine kinases. Inhibits the growth of myeloid and lymphoid cell lines. Induces cell cycle arrest in leukemia and prostate cancer cells.

  • Purity

    98%
  • CAS Number

    438190-29-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione

  • Molecular weight

    273.23
  • Molecular formula

    C11H6F3NO2S
  • PubChem identifier

    1361334
  • Storage instructions

    Shipped at room temperature. Store at -20°C.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM with warming

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2
  • Source

    Synthetic

References

This product has been referenced in:

  • Liong S  et al. Placental Pim-1 expression is increased in obesity and regulates cytokine- and toll-like receptor-mediated inflammation. Placenta 53:101-112 (2017). Read more (PubMed: 28487013) »
  • Lin YW  et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood 115:824-33 (2010). Read more (PubMed: 19965690) »
  • Beharry Z  et al. Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol Cancer Ther 8:1473-83 (2009). Read more (PubMed: 19509254) »
  • Xia Z  et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem 52:74-86 (2009). Read more (PubMed: 19072652) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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