Anti-SMOC1 antibody (ab200219)
Key features and details
- Rabbit polyclonal to SMOC1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-SMOC1 antibody
See all SMOC1 primary antibodies -
Description
Rabbit polyclonal to SMOC1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant fragment corresponding to Human SMOC1 aa 150-400.
Database link: Q9H4F8 -
Positive control
- OV2008 cell lysate. Human fetal stomach tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute in 200 uL sterile distilled water -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab200219 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/200 - 1/1000. Predicted molecular weight: 48 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/200 - 1/1000. Predicted molecular weight: 48 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
Plays essential roles in both eye and limb development. Probale regulator of osteoblast differentiation. -
Tissue specificity
Widely expressed in many tissues with a strongest signal in ovary. No expression in spleen. -
Involvement in disease
Defects in SMOC1 are the cause of ophthalmoacromelic syndrome (OAS) [MIM:206920]. A rare disorder presenting with anophthalmia or microphthalmia and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and olygodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases. -
Sequence similarities
Contains 2 EF-hand domains.
Contains 1 Kazal-like domain.
Contains 2 thyroglobulin type-1 domains. -
Post-translational
modificationsGlycosylated. -
Cellular localization
Secreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane. - Information by UniProt
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Database links
- Entrez Gene: 64093 Human
- Entrez Gene: 64075 Mouse
- Omim: 608488 Human
- SwissProt: Q9H4F8 Human
- SwissProt: Q8BLY1 Mouse
- Unigene: 497349 Human
- Unigene: 273295 Mouse
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Alternative names
- Secreted modular calcium-binding protein 1 antibody
- SMOC-1 antibody
- SMOC1 antibody
see all
Images
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Immunohistochemical analysis of formalin fixed, paraffin embedded human fetal stomach tissue labeling SMOC1 with ab200291 at 1/100.
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Anti-SMOC1 antibody (ab200219) at 1/500 dilution + OV2008 cell lysate
Predicted band size: 48 kDa
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab200219 has been referenced in 2 publications.
- Ao X et al. lincRNA-p21 inhibits the progression of non-small cell lung cancer via targeting miR-17-5p. Oncol Rep 41:789-800 (2019). PubMed: 30535441
- Wang Y & Wu X SMOC1 silencing suppresses the angiotensin II-induced myocardial fibrosis of mouse myocardial fibroblasts via affecting the BMP2/Smad pathway. Oncol Lett 16:2903-2910 (2018). PubMed: 30127878