Product nameAnti-SMOC1 antibody
See all SMOC1 primary antibodies
DescriptionRabbit polyclonal to SMOC1
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Recombinant fragment corresponding to Human SMOC1 aa 178-352.
GSK PTPTMETQPV FDGDEITAPT LWIKHLVIKD SKLNNTNIRN SEKVYSCDQE RQSALEEAQQ NPREGIVIPE CAPGGLYKPV QCHQSTGYCW CVLVDTGRPL PGTSTRYVMP SCESDARAKT TEADDPFKDR ELPGCPEGKK MEFITSLLDA LTTDMVQAIN SAAPTGGGRF SE
Database link: Q9H4F8
- OV2008 cell lysate. Human fetal stomach tissue.
FormLyophilised:Reconstitute in 200 uL sterile distilled water
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab200219 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/200 - 1/1000. Predicted molecular weight: 48 kDa.|
|IHC-P||1/100 - 1/500.|
FunctionPlays essential roles in both eye and limb development. Probale regulator of osteoblast differentiation.
Tissue specificityWidely expressed in many tissues with a strongest signal in ovary. No expression in spleen.
Involvement in diseaseDefects in SMOC1 are the cause of ophthalmoacromelic syndrome (OAS) [MIM:206920]. A rare disorder presenting with anophthalmia or microphthalmia and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and olygodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases.
Sequence similaritiesContains 2 EF-hand domains.
Contains 1 Kazal-like domain.
Contains 2 thyroglobulin type-1 domains.
Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane.
- Information by UniProt
- Secreted modular calcium-binding protein 1 antibody
- SMOC-1 antibody
- SMOC1 antibody
Immunohistochemical analysis of formalin fixed, paraffin embedded human fetal stomach tissue labeling SMOC1 with ab200291 at 1/100.
Anti-SMOC1 antibody (ab200219) at 1/500 dilution + OV2008 cell lysate
Predicted band size: 48 kDa
This product has been referenced in:
- Ao X et al. lincRNA-p21 inhibits the progression of non-small cell lung cancer via targeting miR-17-5p. Oncol Rep 41:789-800 (2019). Read more (PubMed: 30535441) »
- Wang Y & Wu X SMOC1 silencing suppresses the angiotensin II-induced myocardial fibrosis of mouse myocardial fibroblasts via affecting the BMP2/Smad pathway. Oncol Lett 16:2903-2910 (2018). Read more (PubMed: 30127878) »