Overview

  • Product name

  • Description

    Rabbit polyclonal to SMOC1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment corresponding to Human SMOC1 aa 178-352.
    Sequence:

    GSK PTPTMETQPV FDGDEITAPT LWIKHLVIKD SKLNNTNIRN SEKVYSCDQE RQSALEEAQQ NPREGIVIPE CAPGGLYKPV QCHQSTGYCW CVLVDTGRPL PGTSTRYVMP SCESDARAKT TEADDPFKDR ELPGCPEGKK MEFITSLLDA LTTDMVQAIN SAAPTGGGRF SE


    Database link: Q9H4F8

  • Positive control

    • OV2008 cell lysate. Human fetal stomach tissue.

Properties

  • Form

    Lyophilised:Reconstitute in 200 uL sterile distilled water
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG

Applications

Our Abpromise guarantee covers the use of ab200219 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/1000. Predicted molecular weight: 48 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function

    Plays essential roles in both eye and limb development. Probale regulator of osteoblast differentiation.
  • Tissue specificity

    Widely expressed in many tissues with a strongest signal in ovary. No expression in spleen.
  • Involvement in disease

    Defects in SMOC1 are the cause of ophthalmoacromelic syndrome (OAS) [MIM:206920]. A rare disorder presenting with anophthalmia or microphthalmia and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and olygodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases.
  • Sequence similarities

    Contains 2 EF-hand domains.
    Contains 1 Kazal-like domain.
    Contains 2 thyroglobulin type-1 domains.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Secreted modular calcium-binding protein 1 antibody
    • SMOC-1 antibody
    • SMOC1 antibody
    • SMOC1_HUMAN antibody
    • SPARC-related modular calcium-binding protein 1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded human fetal stomach tissue labeling SMOC1 with ab200291 at 1/100.

  • Anti-SMOC1 antibody (ab200219) at 1/500 dilution + OV2008 cell lysate

    Predicted band size: 48 kDa

References

This product has been referenced in:

  • Ao X  et al. lincRNA-p21 inhibits the progression of non-small cell lung cancer via targeting miR-17-5p. Oncol Rep 41:789-800 (2019). Read more (PubMed: 30535441) »
  • Wang Y & Wu X SMOC1 silencing suppresses the angiotensin II-induced myocardial fibrosis of mouse myocardial fibroblasts via affecting the BMP2/Smad pathway. Oncol Lett 16:2903-2910 (2018). Read more (PubMed: 30127878) »
See all 2 Publications for this product

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