Question (42074) | Anti-smooth muscle Myosin heavy chain 11 antibody [1G12] (ab683)

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Question

One customer ordered the antibody ab683, smooth muscle myosin heavy chain 11.

In response they had a request do you know which isoform is recognized by product AB683? SM1A, SM1B, SM2A or SM2B?

Do you have other antibodies available for the detection of this MYH11 gene, do they recognize a certain specific area of SM1A, SM1B, SM2A or SM2B isoform?

Answer

Thank you for contacting us.

The antibody ab683 will recognize SM2A and SM2B:

Human SM2A

http://www.ncbi.nlm.nih.gov/protein/13124875?report=genbank&log$=prottop&blast_rank=8&RID=R93GH1VT016

Human SM2B

http://www.ncbi.nlm.nih.gov/protein/92091583?report=genbank&log$=prottop&blast_rank=10&RID=R93GH1VT016

It will not recognize SM1A or SM1B, but it cannot distinguish between the A and B isoforms of SM2.

For an antibody specific for SM1, we have ab682. This will not react with SM2, but it cannot distinguish between the A and B isoforms of SM1.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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