Overview

  • Product name

  • Description

    Goat polyclonal to Smoothened
  • Host species

    Goat
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-NLMDTELMDADSD

    , corresponding to C terminal amino acids 774-786 of Human Smoothened

  • Positive control

    • Human Bone Marrow lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab58574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 86 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
    • Sequence similarities

      Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • Frizzled family member 11 antibody
      • FZD11 antibody
      • Gx antibody
      • Gx protein antibody
      • Protein Gx antibody
      • SMO antibody
      • SMO_HUMAN antibody
      • SMOH antibody
      • Smoothened frizzled family receptor antibody
      • Smoothened homolog (Drosophila) antibody
      • Smoothened homolog antibody
      • Smoothened homolog precursor (SMO) (Gx protein) antibody
      • Smoothened seven transmembrane spanning receptor antibody
      see all

    Images

    References

    ab58574 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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