SNAP, NO donor (ab120014)
Overview
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Product name
SNAP, NO donor -
Description
NO donor -
Biological description
NO donor. Vasodilator in vitro and in vivo, that does not induce pharmacological tolerance. -
CAS Number
67776-06-1 -
Chemical structure
Properties
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Chemical name
S-Nitroso-N-acetyl-DL-penicillamin -
Molecular weight
220.24 -
Molecular formula
C7H12N2O4S -
PubChem identifier
5231 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(SN=O)C(NC(=O)C)C(=O)O -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Donors / precursors
- Donors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Donors / precursors
- Donors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Donors / precursors
- Donors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Donors / precursors
- Donors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- Donors / precursors
- Donors
Associated products
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Related Products
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References
ab120014 has been referenced in 6 publications.
- Zhou MH et al. Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation. J Biol Chem 290:30616-23 (2015). PubMed: 26507659
- Elies J et al. Inhibition of the cardiac na+ channel nav1.5 by carbon monoxide. J Biol Chem 289:16421-9 (2014). PubMed: 24719320
- Sieber AR et al. Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus. J Neurosci 33:15675-85 (2013). PubMed: 24089475
- Jin XG et al. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. J Biol Chem 286:33190-202 (2011). PubMed: 21813646
- Fenselau H et al. Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons. J Neurosci 31:17383-91 (2011). PubMed: 22131400
- Bright DP & Brickley SG Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus. J Physiol 586:5091-9 (2008). PubMed: 18772202
