Overview

  • Product name

  • Description

    Rabbit polyclonal to SNAT2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human SNAT2 aa 1-76.
    Database link: Q96QD8

  • Positive control

    • WB: A431 whole cell lysate. IHC-P: Human small intestine and panceas tissues. ICC/IF: A431 cells.
  • General notes

     This product was previously labelled as SLC38A2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab237614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 56 kDa.
IHC-P 1/20 - 1/200.

Target

  • Function

    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
  • Tissue specificity

    Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
  • Sequence similarities

    Belongs to the amino acid/polyamine transporter 2 family.
  • Post-translational
    modifications

    Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.
  • Cellular localization

    Cell membrane. Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.
  • Information by UniProt
  • Database links

  • Alternative names

    • Amino acid transporter 2 antibody
    • Amino acid transporter A2 antibody
    • ATA2 antibody
    • KIAA1382 antibody
    • PRO1068 antibody
    • Protein 40-9-1 antibody
    • S38A2_HUMAN antibody
    • SAT2 antibody
    • Slc38a2 antibody
    • SNAT2 antibody
    • Sodium-coupled neutral amino acid transporter 2 antibody
    • Solute carrier family 38 member 2 antibody
    • System A amino acid transporter antibody
    • System A amino acid transporter 2 antibody
    • System A transporter 1 antibody
    • System N amino acid transporter 2 antibody
    see all

Images

  • Anti-SNAT2 antibody (ab237614) at 1/500 dilution + A431 (human epidermoid carcinoma cell line) whole cell lysate

    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 56 kDa

  • Paraffin-embedded human small intestine tissue stained for SNAT2 using ab237614 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human pancreatic tissue stained for SNAT2 using ab237614 at 1/100 dilution in immunohistochemical analysis.

  • A431 (human epidermoid carcinoma cell line) cells stained for SNAT2 (green) using ab237614 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

References

This product has been referenced in:

  • Shang M & Wen Z Increased placental IGF-1/mTOR activity in macrosomia born to women with gestational diabetes. Diabetes Res Clin Pract 146:211-219 (2018). Read more (PubMed: 30389621) »
See 1 Publication for this product

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