SNS-032, cyclin-dependent kinase (CDK) inhibitor (ab219467)

Overview

  • Product name

    SNS-032, cyclin-dependent kinase (CDK) inhibitor
  • Description

    Potent, selective cyclin-dependent kinase (CDK) inhibitor
  • Alternative names

    • BMS-387032
  • Biological description

    Potent, selective inhibitor of cyclin-dependent kinases (CDKs) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). Blocks the cell cycle, inhibits transcription, and induces apoptosis in multiple myeloma RPMI-8226 cells (IC90 = 0.3 µM). Induces apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.

  • Purity

    > 98%
  • CAS Number

    345627-80-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
  • Molecular weight

    380.53
  • Molecular formula

    C17H24N4O2S2
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
  • Source

    Synthetic

References

This product has been referenced in:

  • Chen R  et al. Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res 70:6587-97 (2010). Read more (PubMed: 20663900) »
  • Conroy A  et al. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother Pharmacol 64:723-32 (2009). Read more (PubMed: 19169685) »
  • Chen R  et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood 113:4637-45 (2009). Read more (PubMed: 19234140) »
  • Ali MA  et al. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia 9:370-81 (2007). Read more (PubMed: 17534442) »
  • Misra RN  et al. N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. J Med Chem 47:1719-28 (2004). Read more (PubMed: 15027863) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab219467.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up