Overview

  • Product name
  • Description
    Rabbit polyclonal to SNX3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Synthetic peptide within Human SNX3 aa 77-105 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: O60493

  • Positive control
    • A2058 cell line lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab174123 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab174123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 19 kDa.

Target

  • Function
    Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol-3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.
  • Involvement in disease
    A chromosomal aberration involving SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8) [MIM:601349]. Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported.
  • Sequence similarities
    Belongs to the sorting nexin family.
    Contains 1 PX (phox homology) domain.
  • Domain
    The PX domain mediates specific binding to phosphatidylinositol-3-phosphate (PtdIns(P3)).
  • Post-translational
    modifications
    Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10.
  • Cellular localization
    Early endosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Grd19 antibody
    • MCOPS8 antibody
    • MGC151262 antibody
    • MGC151266 antibody
    • MGC17570 antibody
    • OTTHUMP00000016941 antibody
    • OTTHUMP00000046475 antibody
    • OTTHUMP00000046476 antibody
    • Protein SDP3 antibody
    • SDP3 antibody
    • SNX3 antibody
    • SNX3_HUMAN antibody
    • SNX3A antibody
    • Sorting nexin 3 antibody
    • Sorting nexin 3A antibody
    • Sorting nexin-3 antibody
    see all

Images

  • Anti-SNX3 antibody (ab174123) at 1/100 dilution + A2058 cell line lysate at 35 µg

    Predicted band size: 19 kDa

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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