Recombinant
RabMAb

Recombinant Anti-SOCS2 antibody [EPR2588(2)] (ab109245)

Overview

  • Product name

    Anti-SOCS2 antibody [EPR2588(2)]
    See all SOCS2 primary antibodies
  • Description

    Rabbit monoclonal [EPR2588(2)] to SOCS2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IP, ICC/IFmore details
    Unsuitable for: Flow Cyt or IHC-P
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human SOCS2 aa 1-100 (N terminal). The exact sequence is proprietary.

  • Positive control

    • MCF7 cell lysate, NCCIT cell lysate, K562 cell lysate; HeLa cells
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab109245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 22 kDa.
IP 1/10 - 1/100.
ICC/IF 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt or IHC-P.
  • Target

    • Function

      SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    • Tissue specificity

      High expression in heart, placenta, lung, kidney and prostate.
    • Pathway

      Protein modification; protein ubiquitination.
    • Sequence similarities

      Contains 1 SH2 domain.
      Contains 1 SOCS box domain.
    • Domain

      The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
    • Information by UniProt
    • Database links

    • Alternative names

      • CIS 2 antibody
      • CIS-2 antibody
      • CIS2 antibody
      • Cish 2 antibody
      • Cish2 antibody
      • Cytokine inducible SH2 protein 2 antibody
      • Cytokine-inducible SH2 protein 2 antibody
      • SOCS 2 antibody
      • SOCS-2 antibody
      • Socs2 antibody
      • SOCS2_HUMAN antibody
      • SSI 2 antibody
      • SSI-2 antibody
      • SSI2 antibody
      • STAT induced STAT inhibitor 2 antibody
      • STAT-induced STAT inhibitor 2 antibody
      • STATI 2 antibody
      • STATI2 antibody
      • Suppressor of cytokine signaling 2 antibody
      see all

    Images

    • Immunofluorescent staining of HeLa cells using ab109245 at 1/100 dilution.
    • All lanes : Anti-SOCS2 antibody [EPR2588(2)] (ab109245) at 1/1000 dilution

      Lane 1 : MCF7 cell lysate
      Lane 2 : NCCIT cell lysate
      Lane 3 : K562 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 22 kDa

    References

    ab109245 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Answer

    Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

    I have issued a free of charge replacement, ab92847.

    To check the status of the order please contact our Customer Service team and reference this number.

    Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know.

    I wish you the best of luck with your research.

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