Product nameAnti-SOCS6 antibody - Carboxyterminal end
See all SOCS6 primary antibodies
DescriptionRabbit polyclonal to SOCS6 - Carboxyterminal end
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic peptide within Human SOCS6 aa 500 to the C-terminus (C terminal). The exact sequence is proprietary.
Database link: O14544
- A431 and HeLa cells
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Purification notesAffinity purified
Our Abpromise guarantee covers the use of ab53181 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Perform heat-mediated antigen retrieval with 10mM citrate buffer for 10 minutes, followed by cooling at room temperature for 20 minutes.
FunctionSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesContains 1 SH2 domain.
Contains 1 SOCS box domain.
DomainThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
- Information by UniProt
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This product has been referenced in:
- Cheng L et al. miR-494 inhibits cervical cancer cell proliferation through upregulation of SOCS6 expression. Oncol Lett 15:3075-3080 (2018). Read more (PubMed: 29456720) »
- Carvalho AV et al. SOCS genes expression during physiological and perturbed implantation in bovine endometrium. Reproduction 148:545-57 (2014). Read more (PubMed: 25187621) »