Overview

  • Product name
    Anti-SOCS6 antibody - Carboxyterminal end
    See all SOCS6 primary antibodies
  • Description
    Rabbit polyclonal to SOCS6 - Carboxyterminal end
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human SOCS6 aa 500 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: O14544

  • Positive control
    • A431 and HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab53181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.

Perform heat-mediated antigen retrieval with 10mM citrate buffer for 10 minutes, followed by cooling at room temperature for 20 minutes.

Target

  • Function
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • Domain
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CIS-4 antibody
    • CIS4 antibody
    • Cish4 antibody
    • Cytokine inducible SH2 protein 4 antibody
    • Cytokine-inducible SH2 protein 4 antibody
    • HSPC060 antibody
    • SOCS-4 antibody
    • SOCS-6 antibody
    • SOCS4 antibody
    • Socs6 antibody
    • SOCS6_HUMAN antibody
    • SSI4 antibody
    • STAI4 antibody
    • STAT induced STAT inhibitor 4 antibody
    • STAT4 antibody
    • STATI4 antibody
    • Suppressor of cytokine signaling 4 antibody
    • Suppressor of cytokine signaling 6 antibody
    see all

Images

  • Immunohistochemistry (Paraffin-embedded sections) of ab53181 staining human placenta.

References

This product has been referenced in:
  • Carvalho AV  et al. SOCS genes expression during physiological and perturbed implantation in bovine endometrium. Reproduction 148:545-57 (2014). Read more (PubMed: 25187621) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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