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Epigenetics and Nuclear Signaling Chromatin Modifying Enzymes Acetylation
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Sodium 4-phenylbutyrate, Histone deacetylase inhibitor (ab141253)

  • Datasheet
  • SDS
  • COA
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Functional Studies - Sodium 4-phenylbutyrate, Histone deacetylase inhibitor (ab141253)
  • Cellular activation - Sodium 4-phenylbutyrate, Histone deacetylase inhibitor (ab141253)

Key features and details

  • Histone deacetylase inhibitor
  • CAS Number: 1716-12-7
  • Purity: > 99%
  • Soluble in water to 100 mM and in DMSO to 25 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Sodium 4-phenylbutyrate, Histone deacetylase inhibitor
  • Description

    Histone deacetylase inhibitor
  • Biological description

    Histone deacetylase (HDAC) inhibitor. Able to induce apoptosis, differentiation and promote the maturation of a variety of malignant cells. Inhibits glioma cell proliferation.

  • Purity

    > 99%
  • CAS Number

    1716-12-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Phenylbutyric acid sodium salt
  • Molecular weight

    186.18
  • Molecular formula

    C10H11NaO2
  • PubChem identifier

    5258
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(CCCc1ccccc1)O[Na]
  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • Stem Cells
    • Signaling Pathways
    • Wnt
    • HDACs
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • HDACs
    • Class I
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • HDACs
    • Class II / Hda1 Class
    • Cancer
    • Oncoproteins/suppressors
    • Tumor suppressors
    • Other
    • Cardiovascular
    • Heart
    • Hypertrophy
    • Other
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • HDACs
    • Kits
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Metabolism of lipids and lipoproteins
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism
    • Kits/ Lysates/ Other
    • Kits
    • Cell Damage Kits
    • Cell Damage
    • Biochemicals
    • Pharmacology
    • Signaling
    • Epigenetics
    • Histone Deacetylases (HDAC)
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Deacetylase
    • Histone Deacetylase (HDAC)
    • General
    • Biochemicals
    • Research Area
    • Cancer
    • Epigenetics
    • Histone Deacetylases (HDAC)
    • Biochemicals
    • Research Area
    • Epigenetics
    • Histone Deacetylases (HDAC)

Associated products

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab141253 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies
    Use at an assay dependent concentration.
    Notes
    Functional Studies
    Use at an assay dependent concentration.

    Images

    • Functional Studies - Sodium 4-phenylbutyrate, Histone deacetylase inhibitor (ab141253)
      Functional Studies - Sodium 4-phenylbutyrate, Histone deacetylase inhibitor (ab141253)
      ab70362 staining adiponectin receptor 1 in HepG2 cells treated with sodium 4-phenylbutyrate (ab141253), by ICC/IF. Increase of adiponectin receptor 1 expression correlates with increased concentration of sodium 4-phenylbutyrate, as described in literature.
      The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab141253 (sodium 4-phenylbutyrate) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab70362 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
    • Cellular activation - Sodium 4-phenylbutyrate, Histone deacetylase inhibitor (ab141253)
      Cellular activation - Sodium 4-phenylbutyrate, Histone deacetylase inhibitor (ab141253)Image from Okhovat M A, et al. Plos One, 13(2), e0189267. Fig 1g,; doi: 10.1371/journal.pone.0189267
      The effect of sodium phenylbutyrate (NB) and sodium valproate (NV) on the expression of AHSP in K562 cells. 2D, two days of treatment; 4D, four days of treatment; 6D, six days of treatment.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (2)

    Publishing research using ab141253? Please let us know so that we can cite the reference in this datasheet.

    ab141253 has been referenced in 2 publications.

    • Okhovat MA  et al. The effect of histone deacetylase inhibitors on AHSP expression. PLoS One 13:e0189267 (2018). PubMed: 29389946
    • Qie X  et al. Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage. Front Pharmacol 8:639 (2017). PubMed: 28959203

    Customer reviews and Q&As

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