Sodium ascorbate, bioavailable form of vitamin C  (ab145813)

Overview

  • Product name

    Sodium ascorbate, bioavailable form of vitamin C 
  • Description

    More bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
  • Alternative names

    • L(+)-Ascorbic acid sodium salt
    • Vitamin C sodium salt
  • Biological description

    Has growth inhibiting action in cultured human neoplastic cell lines at high concentrations. Combined with vitamin K3, demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations which is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the effects. Induces DNA single-strand breaks in human cells.

  • Purity

    > 99%
  • CAS Number

    134-03-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    L-Ascorbic acid sodium salt
  • Molecular weight

    201.13
  • Molecular formula

    C6H8O6.Na
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM and in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Singh NP Sodium ascorbate induces DNA single-strand breaks in human cells in vitro. Mutat Res 375:195-203 (1997). Read more (PubMed: 9202729) »
  • Sakagami H  et al. The requirement for and mobilization of calcium during induction by sodium ascorbate and by hydrogen peroxide of cell death. Life Sci 58:1131-8 (1996). Read more (PubMed: 8614264) »
  • Noto V  et al. Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action. Cancer 63:901-6 (1989). Read more (PubMed: 2914296) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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