Product nameSodium nitroprusside, Vasodilator
DescriptionPotent vasodilator working through releasing NO spontaneously in blood.
- Nitroprusside sodium
Potent vasodilating effects in arterioles and venules. Breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate. Decreases the proliferation of vascular smooth muscle cells. Significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 201.37 mM and in water to 201.37 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Emre A et al. Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia-reperfusion model. Clinics (Sao Paulo) 63:91-6 (2008). Read more (PubMed: 18297213) »
- Wink DA et al. The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys 331:241-8 (1996). Read more (PubMed: 8660704) »
- Friederich JA & Butterworth JF Sodium nitroprusside: twenty years and counting. Anesth Analg 81:152-62 (1995). Read more (PubMed: 7598246) »
- Garg UC & Hassid A Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83:1774-7 (1989). Read more (PubMed: 2540223) »