Sodium oxamate, Weak lactate dehydrogenase inhibitor (ab145643)

Overview

  • Product name
    Sodium oxamate, Weak lactate dehydrogenase inhibitor
  • Description
    Weak lactate dehydrogenase inhibitor
  • Biological description
    Weak lactate dehydrogenase inhibitor (IC50 values are 600 and 4400 μM in H460 and A549 cells respectively). Inhibits glycolysis and gluconeogenesis. Pyruvate (ab145036) analog. Decreases extracellular acidification rate.
  • Purity
    > 99%
  • CAS Number
    565-73-1
  • Chemical structure
    Chemical Structure

Properties

  • Molecular weight
    111.03
  • Molecular formula
    C2H2NNaO3
  • PubChem identifier
    5242
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C(=O)(C(=O)[O-])N.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Hall CN  et al. Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing. J Neurosci 32:8940-51 (2012). Read more (PubMed: 22745494) »
  • Wu M  et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292:C125-36 (2007). Read more (PubMed: 16971499) »
  • Yamamoto S H4-isozyme of lactate dehydrogenase in a solution of sodium C chloride--6. The effect of oxalate and oxamate on the molecular weight. Int J Biochem 15:1279-82 (1983). Read more (PubMed: 6628830) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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