Recombinant
RabMAb

Recombinant Anti-Sodium/Hydrogen Exchanger 1/NHE-1 antibody [EPR6975] (ab126725)

Overview

  • Product name

    Anti-Sodium/Hydrogen Exchanger 1/NHE-1 antibody [EPR6975]
    See all Sodium/Hydrogen Exchanger 1/NHE-1 primary antibodies
  • Description

    Rabbit monoclonal [EPR6975] to Sodium/Hydrogen Exchanger 1/NHE-1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Sodium/Hydrogen Exchanger 1/NHE-1 aa 50-150 (extracellular).
    Database link: P19634

  • Positive control

    • MOLT4 and Caco 2 cell lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Previously labelled as Sodium / Hydrogen Exchanger 1.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab126725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 130 kDa (predicted molecular weight: 91 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
    • Tissue specificity

      Kidney and intestine.
    • Sequence similarities

      Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.
      O-glycosylated.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • amiloride-sensitive antibody
      • APNH antibody
      • APNH1 antibody
      • FLJ42224 antibody
      • Na Li countertransporter antibody
      • Na(+)/H(+) antiporter antibody
      • Na(+)/H(+) exchanger 1 antibody
      • Na+ H+ antiporter amiloride-sensitive antibody
      • Na+ H+ antiporter antibody
      • Na+ H+ exchanger 1 antibody
      • NHE-1 antibody
      • NHE1 antibody
      • OTTHUMP00000004468 antibody
      • SL9A1_HUMAN antibody
      • SLC9A1 antibody
      • Sodium / Hydrogen Exchanger 1 antibody
      • Sodium hydrogen exchanger 1 antibody
      • Sodium/hydrogen exchanger 1 antibody
      • solute carrier family 9 antibody
      • Solute carrier family 9 member 1 antibody
      • Solute carrier family 9 sodium hydrogen exchanger isoform 1 antiporter Na+ H+ amiloride sensitive antibody
      • Solute carrier family 9 subfamily A (NHE1 cation proton antiporter 1) member 1 antibody
      • Solute carrier family 9 subfamily A member 1 antibody
      see all

    Images

    • All lanes : Anti-Sodium/Hydrogen Exchanger 1/NHE-1 antibody [EPR6975] (ab126725) at 1/1000 dilution

      Lane 1 : MOLT4 cell lysate
      Lane 2 : Caco 2 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 91 kDa

    References

    This product has been referenced in:

    • De Smet S  et al. Physiological Adaptations to Hypoxic vs. Normoxic Training during Intermittent Living High. Front Physiol 8:347 (2017). WB ; Human . Read more (PubMed: 28620311) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab126725.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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