Key features and details
- Rabbit polyclonal to Solute carrier family 22 member 5
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-Solute carrier family 22 member 5 antibody
DescriptionRabbit polyclonal to Solute carrier family 22 member 5
Tested applicationsSuitable for: ICC/IF, WBmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat, Baboon
Recombinant fragment corresponding to Human Solute carrier family 22 member 5 aa 1-180.
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC RVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPG RDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFF VGVLLGSFISGQLSDRFGRKNVLFVTMGMQ
Database link: O76082
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab180757 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent concentration.|
|WB||1/500 - 1/2000. Predicted molecular weight: 63 kDa.|
FunctionSodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Tissue specificityStrongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
Involvement in diseaseDefects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP) [MIM:212140]. CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy.
Sequence similaritiesBelongs to the major facilitator superfamily. Organic cation transporter family.
- Information by UniProt
- CDSP antibody
- High-affinity sodium-dependent carnitine cotransporter antibody
- OCTN2 antibody
Immunocytochemistry/Immunofluorescence analysis of MCF7 cells using ab180757. Blue DAPI for nuclear staining.
All lanes : Anti-Solute carrier family 22 member 5 antibody (ab180757) at 1/500 dilution
Lane 1 : MCF7 cell lysate
Lane 2 : OVCAR3 cell lysate
Lane 3 : A549 cell lysate
Lane 4 : DU145 cell lysate
Lane 5 : SW480 cell lysate
Lane 6 : Mouse intestine cell lysate
Lane 7 : Mouse kidney cell lysate
Predicted band size: 63 kDa
ab180757 has been referenced in 1 publication.
- Sekhar GN et al. Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer's disease. Fluids Barriers CNS 16:38 (2019). PubMed: 31842924