Recombinant
RabMAb

Recombinant Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083)

Overview

  • Product name

    Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7]
    See all Somatostatin Receptor 1/SSTR1 primary antibodies
  • Description

    Rabbit monoclonal [UMB7] to Somatostatin Receptor 1/SSTR1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Somatostatin Receptor 1/SSTR1 aa 350-450. The exact sequence is proprietary.

  • Positive control

    • Human fetal lung and Human small intestine lysates; 2936E cells.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

     This product was previously labelled as Somatostatin Receptor 1

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab137083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 43 kDa.
ICC/IF 1/250 - 1/500.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
    • Tissue specificity

      Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization

      Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • G-protein coupled receptor antibody
      • Somatostatin R1 antibody
      • Somatostatin receptor 1 antibody
      • Somatostatin receptor isoform 1 antibody
      • Somatostatin receptor type 1 antibody
      • SRIF 2 antibody
      • SRIF-2 antibody
      • SRIF2 antibody
      • SS-1-R antibody
      • SS1 R antibody
      • SS1-R antibody
      • SS1R antibody
      • SSR1_HUMAN antibody
      • SSTR 1 antibody
      • Sstr1 antibody
      see all

    Images

    • All lanes : Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083) at 1/500 dilution

      Lane 1 : Human fetal lung lysates
      Lane 2 : Human small intestine lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 43 kDa

    • Immunofluorescent analysis of 2936E cells labelling Somatostatin Receptor 1/SSTR1 with ab137083 at 1/250 dilution.

    References

    This product has been referenced in:

    • Zou Y  et al. Expression and selective activation of somatostatin receptor subtypes induces cell cycle arrest in cancer cells. Oncol Lett 17:1723-1731 (2019). Read more (PubMed: 30675231) »
    • Venegas-Moreno E  et al. Association between dopamine and somatostatin receptor expression and pharmacological response to somatostatin analogues in acromegaly. J Cell Mol Med 22:1640-1649 (2018). IHC ; Human . Read more (PubMed: 29266696) »
    See all 7 Publications for this product

    Customer reviews and Q&As

    This product is known to not work in this application or species.
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Human Tissue sections (Folicular Thyroid Cell)
    Antigen retrieval step
    Heat mediated
    Permeabilization
    No
    Specification
    Folicular Thyroid Cell
    Blocking step
    Max Polymer Detection System as blocking agent for 5 minute(s) · Concentration: 0% · Temperature: 25°C
    Fixative
    Formaldehyde

    Abcam user community

    Verified customer

    Submitted May 29 2015

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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