Overview

  • Product name
    Anti-Somatostatin Receptor 2 antibody
    See all Somatostatin Receptor 2 primary antibodies
  • Description
    Rabbit polyclonal to Somatostatin Receptor 2
  • Host species
    Rabbit
  • Specificity
    This antibody is specific for Somatostatin R2
  • Tested applications
    Suitable for: WB, ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:

    C-ERSDSKQDKSRLNETTETQRT

    conjugated to KLH, corresponding to C terminal amino acids 339-359 of Rat Somatostatin Receptor 2.

Properties

Applications

Our Abpromise guarantee covers the use of ab9550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Can be blocked with Somatostatin Receptor 2 peptide (ab218996). (75-85 kDa band expected).Multiple smaller MW bands may also be seen.
ICC/IF 1/100 - 1/250.
IHC-P Use at an assay dependent dilution.

Target

  • Function
    Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
  • Tissue specificity
    Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Somatostatin receptor type 2 antibody
    • SRIF-1 antibody
    • SRIF1 antibody
    • SS-2-R antibody
    • SS2-R antibody
    • SS2R antibody
    • SSR2_HUMAN antibody
    • SST2 antibody
    • SSTR2 antibody
    see all

References

This product has been referenced in:
  • Zhang L  et al. Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models. Contrast Media Mol Imaging 2017:9481276 (2017). Read more (PubMed: 29097943) »
  • Gradiz R  et al. MIA PaCa-2 and PANC-1 - pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors. Sci Rep 6:21648 (2016). IHC . Read more (PubMed: 26884312) »
See all 5 Publications for this product

Customer reviews and Q&As

1-4 of 4 Abreviews or Q&A

Question
Answer

I am very pleased to hear you would like to accept our offer and test ab9550 in WB on Chicken. This code will give you 1 free PRIMARY ANTIBODY before the expiration date. To redeem this offer, please submit an Abreview for Chicken and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews. Remember, we publish both positive and negative Abreviews on our datasheets so please submit the results of your tests. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code. Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research. The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount. Thank you very much for your interest in ab9550. To our knowledge, ab/xxx/ has not been tested in chicken. Therefore, I can offer a discount off a future purchase if you buy ab9550 now, test it in WB on chicken and submit feedback to us in the form of an Abreview. It doesn’t matter whether the Abreview is positive or negative, we would just really like to receive your feedback. The discount would be to the value of 1 free PRIMARY ANTIBODY. If you are interested in this offer, please follow these steps: 1. Reply to this e-mail to let me know that you would like to proceed and test ab9550 in (UNTESTED APP/SPECIES). I will then send a discount code. This code must be issued before purchasing ab(XXX) so please wait for my reply before ordering. 2. Purchase ab(XXX) either by phone, fax, or online (www.abcam.com). 3. Test it in (UNTESTED APP/SPECIES). 4. Let us know the results, positive or negative, using our Abreview system (this will take about 10 minutes and images are great if you have them!). To find out how to submit an Abreview, please visit: https://www.abcam.com/abreviews. 5. After the review is submitted to us, the discount code becomes active. Simply place your new order by phone, fax, or on the web and mention the discount code. The discount can be redeemed for any [PRIMARY ANTIBODY /PROTEIN] ordered and the discount code is valid for 4 months after issue. We are always pleased to obtain feedback about our products and any information is greatly appreciated! Even if ab(XXX) turns out to be unsuitable for (UNTESTED APP/SPECIES), you will still receive the discount on your next purchase after your Abreview has been submitted. Please let me know if you have any questions about this offer and I would be happy to help you further. The Terms and Conditions of this offer can be found at: www.abcam.com/collaborationdiscount.

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Answer

Thank you for contacting us.

A quick search of SSTR2 does show low expression in tissues of the CNS with the exception of granular and molecular layer cells in the cerebellum. However, if this protein is present in spinal tissue and you are using it in mouse, rat or humans tissues this antibody should recognize the protein.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Answer

Ab9550 was tested in immunofluorescence, but has not yet been tested with paraffin-embedded or frozen sections in IHC.

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Answer

Thank you for your enquiry. To our knowledge, this antibody has yet to be tested in IHC; I cannot recommned a type of fixation at this time. All tested applications are specified on Abcam product datasheets. If you decide to go ahead and purchase this product, please let us know how you get on and in return we will forward a reward of your choice, typically an Amazon gift voucher.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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