Key features and details
- Potent and selective Smoothened antagonist
- CAS Number: 956697-53-3
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameSonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist
DescriptionPotent and selective Smoothened antagonist
Potent and selective Smoothened antagonist. Blocks Hedgehog signaling pathway activity (IC50 = 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays. Anti-tumor activity in mouse medulloblastoma allograft model.
Chemical namerel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'- (trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
Storage instructionsShipped at room temperature. Store at -20°C.
Solubility overviewSoluble in DMSO to 50 mM
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab269876 has not yet been referenced specifically in any publications.