Overview

  • Product name

    Sophocarpine, HERG Kchannel blocker
  • Description

    HERG K+ channel blocker and Na+ channel inward current inhibitor
  • Biological description

    HERG K+ channel blocker (IC50 = 100-300 μM) and Na+ channel inward current inhibitor. Activates the AMPK signaling pathway. Inhibits Coxsackie B virus. Shows hepatoprotective and antiviral effects in vivo.
  • CAS Number

    6483-15-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Song CY  et al. Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway. Toxicol In Vitro 27:1065-71 (2013). Read more (PubMed: 23395669) »
  • Zhang S  et al. Sophocarpine attenuates the Na(+)-dependent Ca2(+) overload induced by Anemonia sulcata toxin-increased late sodium current in rabbit ventricular myocytes. J Cardiovasc Pharmacol 60:357-66 (2012). Read more (PubMed: 23064241) »
  • Zhao XL  et al. HERG K+ channel blockade by the novel antiviral drug sophocarpine. Biol Pharm Bull 31:627-32 (2008). Read more (PubMed: 18379053) »

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