Sorafenib, multikinase inhibitor (ab141966)

Overview

  • Product name

    Sorafenib, multikinase inhibitor
  • Description

    Potent multikinase inhibitor
  • Alternative names

    • BAY 43-9006
    • Nexavar
  • Biological description

    Potent multikinase inhibitor that targets the RAF/MEK/ERK pathway in tumor cells, and tyrosine kinases involved in tumor angiogenesis, oncogenesis, and maintenance of the tumor microenvironment. Inhibits Raf-1, B-Raf, VEGFR-2, VEGFR-3, PDGFR-β, Flt3, c-KIT and FGFR-1 (IC50 values are 6 nM, 22 nM, 90 nM, 20 nM, 57 nM, 58 nM, 68 nM and 580 nM in cell-free assays, respectively).

  • Purity

    > 98%
  • CAS Number

    284461-73-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
  • Molecular weight

    464.82
  • Molecular formula

    C21H16ClF3N4O3
  • PubChem identifier

    216239
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Davoudi ET  et al. Sorafenib in renal cell carcinoma. Pak J Pharm Sci 27:203-8 (2014). Read more (PubMed: 24374450) »
  • Liu L  et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 66:11851-8 (2006). Read more (PubMed: 17178882) »
  • Adnane L  et al. Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol 407:597-612 (2006). Read more (PubMed: 16757355) »
  • Wilhelm SM  et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64:7099-109 (2004). Read more (PubMed: 15466206) »

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