Overview

  • Product name

    Anti-Sorbitol Dehydrogenase antibody
    See all Sorbitol Dehydrogenase primary antibodies
  • Description

    Rabbit polyclonal to Sorbitol Dehydrogenase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Full length protein corresponding to Human Sorbitol Dehydrogenase.
    Database link: Q00796

  • Positive control

    • HT29 cell lysate; mouse liver and kidney lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab185705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 38 kDa.
IHC-P 1/50 - 1/200.
ICC/IF Use at an assay dependent concentration.

Target

  • Function

    Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
  • Tissue specificity

    Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
  • Sequence similarities

    Belongs to the zinc-containing alcohol dehydrogenase family.
  • Cellular localization

    Mitochondrion membrane. Cell projection > cilium > flagellum. Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
  • Information by UniProt
  • Database links

  • Alternative names

    • DHSO_HUMAN antibody
    • L iditol 2 dehydrogenase antibody
    • L-iditol 2-dehydrogenase antibody
    • OTTHUMP00000161939 antibody
    • SDH antibody
    • Sorbitol dehydrogenase 1 antibody
    • Sorbitol dehydrogenase antibody
    • SORD 1 antibody
    • SORD antibody
    • SORD1 antibody
    see all

Images

  • All lanes : Anti-Sorbitol Dehydrogenase antibody (ab185705) at 1/500 dilution

    Lane 1 : HT29 cell lysate
    Lane 2 : mouse liver lysate
    Lane 3 : mouse kidney lysate

    Predicted band size: 38 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling Sorbitol Dehydrogenase with ab185705 at 1/200. Magnification: 200x.
  • Immunocytochemistry/Immunofluorescence analysis of MCF7 cells using ab185705. Blue DAPI for nuclear staining.

References

This product has been referenced in:

  • Wu Y  et al. Quantitative Proteomic Analysis of Human Seminal Plasma from Normozoospermic and Asthenozoospermic Individuals. Biomed Res Int 2019:2735038 (2019). Read more (PubMed: 30984777) »
See 1 Publication for this product

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