Product nameAnti-SorLA antibody
See all SorLA primary antibodies
DescriptionGoat polyclonal to SorLA
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse
Predicted to work with: Rat, Rabbit, Cow, Dog, Human
- Mouse brain lysate
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab22814 is purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Our Abpromise guarantee covers the use of ab22814 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Peptide ELISA: antibody detection limit dilution 1:4,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionLikely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
Tissue specificityExpressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
Sequence similaritiesBelongs to the SORL1 family.
Contains 5 BNR repeats.
Contains 1 EGF-like domain.
Contains 6 fibronectin type-III domains.
Contains 11 LDL-receptor class A domains.
Contains 5 LDL-receptor class B repeats.
modificationsThe propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
- Information by UniProt
- C11orf32 antibody
- FLJ21930 antibody
- FLJ39258 antibody
Anti-SorLA antibody (ab22814) at 0.3 µg/ml + Mouse brain lysate at 35 µg
Developed using the ECL technique.
Predicted band size: 246 kDa
Observed band size: 250 kDa why is the actual band size different from the predicted?
Sample incubated with primary antibody for 1 hour.
ab22814 has not yet been referenced specifically in any publications.