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    sorlasorl1-antibody-ab22814.pdf

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Neuroscience Cell Adhesion Proteins Membrane Proteins
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Anti-SorLA/SORL1 antibody (ab22814)

  • Datasheet
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Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)
  • Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)

Key features and details

  • Goat polyclonal to SorLA/SORL1
  • Suitable for: ICC/IF
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human SorLA/SORL1 protein (ab114683)
Secondary
Product image
Donkey Anti-Goat IgG H&L (HRP) (ab97110)

View more associated products

Overview

  • Product name

    Anti-SorLA/SORL1 antibody
    See all SorLA/SORL1 primary antibodies
  • Description

    Goat polyclonal to SorLA/SORL1
  • Host species

    Goat
  • Tested Applications & Species

    Application Species
    ICC/IF
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to Human SorLA/SORL1 aa 2203-2214 (C terminal).
    Sequence:

    TGFSDDVPMVIA

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Mouse brain lysate
  • General notes

     This product was previously labelled as SorLA

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab22814 is purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Cell Adhesion Proteins
    • Membrane Proteins
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Alzheimer's disease
    • Other
    • Signal Transduction
    • Protein Trafficking
    • Golgi Proteins
    • Signal Transduction
    • Metabolism
    • Lipid metabolism

Associated products

  • Compatible Secondaries

    • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
    • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
  • Isotype control

    • Goat IgG, polyclonal - Isotype Control (ab37373)
  • Recombinant Protein

    • Recombinant Human SorLA/SORL1 protein (ab114683)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab22814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC/IF
Human
All applications
Rat
Rabbit
Cow
Dog
Application Abreviews Notes
ICC/IF
Use a concentration of 10 µg/ml.
Notes
ICC/IF
Use a concentration of 10 µg/ml.

Target

  • Function

    Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
  • Tissue specificity

    Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
  • Sequence similarities

    Belongs to the SORL1 family.
    Contains 5 BNR repeats.
    Contains 1 EGF-like domain.
    Contains 6 fibronectin type-III domains.
    Contains 11 LDL-receptor class A domains.
    Contains 5 LDL-receptor class B repeats.
  • Post-translational
    modifications

    The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession Q92673 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 6653 Human
    • Entrez Gene: 300652 Rat
    • Omim: 602005 Human
    • SwissProt: Q92673 Human
    • SwissProt: Q9R0N2 Rat
    • Unigene: 368592 Human
    • Alternative names

      • C11orf32 antibody
      • FLJ21930 antibody
      • FLJ39258 antibody
      • gp250 antibody
      • LDLR relative with 11 ligand binding repeats antibody
      • LDLR relative with 11 ligand-binding repeats antibody
      • Low density lipoprotein receptor relative with 11 ligand binding repeats antibody
      • Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody
      • LR 11 antibody
      • LR11 antibody
      • LRP 9 antibody
      • LRP9 antibody
      • Mosaic protein LR11 antibody
      • SORL 1 antibody
      • SORL_HUMAN antibody
      • SORL1 antibody
      • SorLA 1 antibody
      • SorLA antibody
      • SorLA-1 antibody
      • Sortilin related receptor antibody
      • Sortilin related receptor L(DLR class) A repeats containing antibody
      • Sortilin-related receptor antibody
      • Sorting protein related receptor containing LDLR class A repeats antibody
      • Sorting protein-related receptor containing LDLR class A repeats antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)
      Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)

      Immunocytochemistry/ Immunofluorescence of HepG2 staining SorLA/SORL1 using ab22814 at 10 μg/ml followed by Alexa Fluor 488 secondary antibody 2 μg/ml

      The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml).

    • Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)
      Immunocytochemistry/ Immunofluorescence - Anti-SorLA/SORL1 antibody (ab22814)

      Immunocytochemistry/ Immunofluorescence of A431 staining SorLA/SORL1 using ab22814 at 10 μg/ml followed by Alexa Fluor 488 secondary antibody 2 μg/ml

      The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml).

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab22814? Please let us know so that we can cite the reference in this datasheet.

    ab22814 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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