Product nameAnti-SorLA/SORL1 antibody - C-terminal
See all SorLA/SORL1 primary antibodies
DescriptionRabbit polyclonal to SorLA/SORL1 - C-terminal
Tested applicationsSuitable for: WBmore details
Unsuitable for: IP
Species reactivityReacts with: Human
Predicted to work with: Horse, Rhesus monkey
Synthetic peptide within Human SorLA/SORL1 aa 2164-2214 (C terminal). The exact sequence is proprietary.
Database link: Q92673
- WB: HeLa, HEK-293T and Jurkat whole cell lysates.
This product was previously labelled as SorLA
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate
pH 7 to 8
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab226339 was affinity purified using an epitope specific to SorLA/SORL1 immobilized on solid support.
Our Abpromise guarantee covers the use of ab226339 in the following tested applications.
|WB||1/2000 - 1/10000. Predicted molecular weight: 248 kDa.|
FunctionLikely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
Tissue specificityExpressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
Sequence similaritiesBelongs to the SORL1 family.
Contains 5 BNR repeats.
Contains 1 EGF-like domain.
Contains 6 fibronectin type-III domains.
Contains 11 LDL-receptor class A domains.
Contains 5 LDL-receptor class B repeats.
modificationsThe propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
- Information by UniProt
- C11orf32 antibody
- FLJ21930 antibody
- FLJ39258 antibody
All lanes : Anti-SorLA/SORL1 antibody - C-terminal (ab226339) at 0.1 µg/ml
Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate
Lysates/proteins at 50 µg per lane.
Developed using the ECL technique.
Predicted band size: 248 kDa
Exposure time: 3 seconds
Cell lysates were prepared using NETN lysis buffer.
ab226339 has not yet been referenced specifically in any publications.