Overview

  • Product name

    Anti-SorLA/SORL1 antibody - C-terminal
    See all SorLA/SORL1 primary antibodies
  • Description

    Rabbit polyclonal to SorLA/SORL1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Horse, Rhesus monkey
  • Immunogen

    Synthetic peptide within Human SorLA/SORL1 aa 2164-2214 (C terminal). The exact sequence is proprietary.
    Database link: Q92673

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat whole cell lysates.
  • General notes

     This product was previously labelled as SorLA

     

Properties

Applications

Our Abpromise guarantee covers the use of ab226339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 248 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
    • Tissue specificity

      Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
    • Sequence similarities

      Belongs to the SORL1 family.
      Contains 5 BNR repeats.
      Contains 1 EGF-like domain.
      Contains 6 fibronectin type-III domains.
      Contains 11 LDL-receptor class A domains.
      Contains 5 LDL-receptor class B repeats.
    • Post-translational
      modifications

      The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • C11orf32 antibody
      • FLJ21930 antibody
      • FLJ39258 antibody
      • gp250 antibody
      • LDLR relative with 11 ligand binding repeats antibody
      • LDLR relative with 11 ligand-binding repeats antibody
      • Low density lipoprotein receptor relative with 11 ligand binding repeats antibody
      • Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody
      • LR 11 antibody
      • LR11 antibody
      • LRP 9 antibody
      • LRP9 antibody
      • Mosaic protein LR11 antibody
      • SORL 1 antibody
      • SORL_HUMAN antibody
      • SORL1 antibody
      • SorLA 1 antibody
      • SorLA antibody
      • SorLA-1 antibody
      • Sortilin related receptor antibody
      • Sortilin related receptor L(DLR class) A repeats containing antibody
      • Sortilin-related receptor antibody
      • Sorting protein related receptor containing LDLR class A repeats antibody
      • Sorting protein-related receptor containing LDLR class A repeats antibody
      see all

    Images

    • All lanes : Anti-SorLA/SORL1 antibody - C-terminal (ab226339) at 0.1 µg/ml

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Predicted band size: 248 kDa


      Exposure time: 3 seconds


      Cell lysates were prepared using NETN lysis buffer.

    References

    ab226339 has not yet been referenced specifically in any publications.

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