Anti-Sortilin/NT3 antibody (ab16640)

Knockout Tested Rabbit polyclonal Sortilin/NT3 antibody. Validated in WB, IP, IHC, ICC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Cow, Human. Cited in 48 publication(s).

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ab16640 has been referenced in 50 publications.

  • Sun Z  et al. RAGE/galectin-3 yields intraplaque calcification transformation via sortilin. Acta Diabetol N/A:N/A (2019). PubMed: 30603868
  • Xu SY  et al. Regional and Cellular Mapping of Sortilin Immunoreactivity in Adult Human Brain. Front Neuroanat 13:31 (2019). PubMed: 30914927
  • Chen C  et al. Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice. J Lipid Res 60:539-549 (2019). PubMed: 30670473
  • Robinson-McCarthy LR  et al. Reconstruction of the cell entry pathway of an extinct virus. PLoS Pathog 14:e1007123 (2018). PubMed: 30080900
  • Rhost S  et al. Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion. Breast Cancer Res 20:137 (2018). PubMed: 30454027
  • Itoh S  et al. Dimerization of sortilin regulates its trafficking to extracellular vesicles. J Biol Chem 293:4532-4544 (2018). PubMed: 29382723
  • Zhou FQ  et al. Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques. Alzheimers Res Ther 10:40 (2018). IHC . PubMed: 29690919
  • Hagita S  et al. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep 8:9006 (2018). PubMed: 29899496
  • Al-Akhrass H  et al. Sortilin limits EGFR signaling by promoting its internalization in lung cancer. Nat Commun 8:1182 (2017). PubMed: 29084952
  • Pan X  et al. Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Mol Biol Cell 28:1667-1675 (2017). PubMed: 28450454
  • Li J  et al. Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1. J Biol Chem 292:146-160 (2017). PubMed: 27881673
  • Brasacchio D  et al. Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization. Cell Death Differ 24:961-970 (2017). PubMed: 28060382
  • Li J  et al. Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice. FEBS Lett 591:1018-1028 (2017). PubMed: 28236654
  • Hu X  et al. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum. Front Neuroanat 11:45 (2017). PubMed: 28638323
  • Ogawa K  et al. Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors. Atherosclerosis 249:110-5 (2016). PubMed: 27085161
  • Li J  et al. An obligatory role for neurotensin in high-fat-diet-induced obesity. Nature 533:411-5 (2016). PubMed: 27193687
  • Pinet S  et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells. Oncotarget 7:50349-50364 (2016). PubMed: 27385098
  • Sparks RP  et al. Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. Biochem Biophys Res Commun 478:546-52 (2016). PubMed: 27495870
  • Teo WX  et al. Sortilin is associated with the chlamydial inclusion and is modulated during infection. Biol Open 5:429-35 (2016). PubMed: 26962046
  • Nakazawa T  et al. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun 7:10594 (2016). PubMed: 26839058
  • Patel AB  et al. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A N/A:N/A (2016). PubMed: 27663735
  • Campbell C  et al. Sortilin regulates sorting and secretion of Sonic hedgehog. J Cell Sci 129:3832-3844 (2016). PubMed: 27632999
  • Lui H  et al. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell 165:921-35 (2016). IHC ; Mouse . PubMed: 27114033
  • Yang Z  et al. Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation. FASEB J 30:1037-50 (2016). PubMed: 26581601
  • Gowrishankar S  et al. Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques. Proc Natl Acad Sci U S A 112:E3699-708 (2015). PubMed: 26124111
  • Wessels JM  et al. Estrogen induced changes in uterine brain-derived neurotrophic factor and its receptors. Hum Reprod 30:925-36 (2015). PubMed: 25662808
  • Ghaemimanesh F  et al. Production and Characterization of a Novel Monoclonal Antibody Against Human Sortilin. Monoclon Antib Immunodiagn Immunother 34:390-5 (2015). PubMed: 26683178
  • Ezkurdia N  et al. Inhibition of neuronal apoptosis and axonal regression ameliorates sympathetic atrophy and hemodynamic alterations in portal hypertensive rats. PLoS One 9:e84374 (2014). WB . PubMed: 24400086
  • Campagnolo L  et al. Sortilin expression is essential for pro-nerve growth factor-induced apoptosis of rat vascular smooth muscle cells. PLoS One 9:e84969 (2014). IF, ICC . PubMed: 24404198
  • Tsika E  et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet N/A:N/A (2014). PubMed: 24740878
  • Li J  et al. Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice. J Biol Chem 289:22437-49 (2014). WB ; Mouse . PubMed: 24986865
  • Mbikay M  et al. Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture. FEBS Open Bio 4:755-62 (2014). PubMed: 25349780
  • Klingenberg R  et al. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123:1323-34 (2013). WB ; Mouse . PubMed: 23426179
  • Bi L  et al. Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. J Lipid Res 54:2754-62 (2013). Mouse . PubMed: 23904453
  • De Muynck L  et al. The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding. Neurobiol Aging 34:2541-7 (2013). IP ; Zebrafish . PubMed: 23706646
  • Lee WC  et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet N/A:N/A (2013). WB, ICC/IF ; Human . PubMed: 24163244
  • Mufson EJ  et al. Hippocampal proNGF signaling pathways and ß-amyloid levels in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol 71:1018-29 (2012). PubMed: 23095849
  • Prabakaran T  et al. Mannose 6-phosphate receptor and sortilin mediated endocytosis of a-galactosidase A in kidney endothelial cells. PLoS One 7:e39975 (2012). PubMed: 22768187
  • Strong A  et al. Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest 122:2807-16 (2012). PubMed: 22751103
  • Prabakaran T  et al. Receptor-mediated endocytosis of a-galactosidase A in human podocytes in Fabry disease. PLoS One 6:e25065 (2011). PubMed: 21949853
  • Terry AV  et al. Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. Physiol Behav 102:149-57 (2011). WB ; Rat . PubMed: 21059364
  • Yang M  et al. Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing. J Biol Chem 286:16272-84 (2011). IP ; Human, Rat . PubMed: 21357693
  • Bao JX  et al. Activation of membrane NADPH oxidase associated with lysosome-targeted acid sphingomyelinase in coronary endothelial cells. Antioxid Redox Signal 12:703-12 (2010). Flow Cyt ; Cow . PubMed: 19761405
  • Jedrychowski MP  et al. Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem 285:104-14 (2010). WB ; Mouse, Rat . PubMed: 19864425
  • Wu LL  et al. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem 285:5614-23 (2010). WB ; Human . PubMed: 19996106
  • Kiss M  et al. Sortilin is expressed in cultured human keratinocytes and is regulated by cutaneous neuropeptides. J Invest Dermatol 130:2553-60 (2010). WB, IHC ; Human . PubMed: 20613775
  • Hu F  et al. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron 68:654-67 (2010). PubMed: 21092856
  • Fan YJ  et al. Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats. Eur J Neurosci 27:2380-90 (2008). PubMed: 18430030
  • Nelson TJ & Alkon DL Protection against beta-amyloid-induced apoptosis by peptides interacting with beta-amyloid. J Biol Chem 282:31238-49 (2007). WB ; Rat . PubMed: 17761669
  • Sánchez E  et al. SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor. ASN Neuro 7:N/A (0). WB . PubMed: 26297037

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