Anti-Sortilin/NT3 antibody (ab16640)

Knockout Tested Rabbit polyclonal Sortilin/NT3 antibody. Validated in WB, IP, IHC, ICC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Cow, Human. Cited in 48 publication(s).

Publishing research using ab16640? Please let us know so that we can cite the reference in this datasheet.

ab16640 has been referenced in 50 publications.

  • Sun Z  et al. RAGE/galectin-3 yields intraplaque calcification transformation via sortilin. Acta Diabetol N/A:N/A (2019). PubMed: 30603868
  • Xu SY  et al. Regional and Cellular Mapping of Sortilin Immunoreactivity in Adult Human Brain. Front Neuroanat 13:31 (2019). PubMed: 30914927
  • Chen C  et al. Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice. J Lipid Res 60:539-549 (2019). PubMed: 30670473
  • Robinson-McCarthy LR  et al. Reconstruction of the cell entry pathway of an extinct virus. PLoS Pathog 14:e1007123 (2018). PubMed: 30080900
  • Rhost S  et al. Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion. Breast Cancer Res 20:137 (2018). PubMed: 30454027
  • Itoh S  et al. Dimerization of sortilin regulates its trafficking to extracellular vesicles. J Biol Chem 293:4532-4544 (2018). PubMed: 29382723
  • Zhou FQ  et al. Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques. Alzheimers Res Ther 10:40 (2018). IHC . PubMed: 29690919
  • Hagita S  et al. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep 8:9006 (2018). PubMed: 29899496
  • Al-Akhrass H  et al. Sortilin limits EGFR signaling by promoting its internalization in lung cancer. Nat Commun 8:1182 (2017). PubMed: 29084952
  • Pan X  et al. Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Mol Biol Cell 28:1667-1675 (2017). PubMed: 28450454
  • Li J  et al. Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1. J Biol Chem 292:146-160 (2017). PubMed: 27881673
  • Brasacchio D  et al. Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization. Cell Death Differ 24:961-970 (2017). PubMed: 28060382
  • Li J  et al. Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice. FEBS Lett 591:1018-1028 (2017). PubMed: 28236654
  • Hu X  et al. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum. Front Neuroanat 11:45 (2017). PubMed: 28638323
  • Ogawa K  et al. Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors. Atherosclerosis 249:110-5 (2016). PubMed: 27085161
  • Li J  et al. An obligatory role for neurotensin in high-fat-diet-induced obesity. Nature 533:411-5 (2016). PubMed: 27193687
  • Pinet S  et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells. Oncotarget 7:50349-50364 (2016). PubMed: 27385098
  • Sparks RP  et al. Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. Biochem Biophys Res Commun 478:546-52 (2016). PubMed: 27495870
  • Teo WX  et al. Sortilin is associated with the chlamydial inclusion and is modulated during infection. Biol Open 5:429-35 (2016). PubMed: 26962046
  • Nakazawa T  et al. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun 7:10594 (2016). PubMed: 26839058
  • Patel AB  et al. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A N/A:N/A (2016). PubMed: 27663735
  • Campbell C  et al. Sortilin regulates sorting and secretion of Sonic hedgehog. J Cell Sci 129:3832-3844 (2016). PubMed: 27632999
  • Lui H  et al. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell 165:921-35 (2016). IHC ; Mouse . PubMed: 27114033
  • Yang Z  et al. Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation. FASEB J 30:1037-50 (2016). PubMed: 26581601
  • Gowrishankar S  et al. Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques. Proc Natl Acad Sci U S A 112:E3699-708 (2015). PubMed: 26124111
  • Wessels JM  et al. Estrogen induced changes in uterine brain-derived neurotrophic factor and its receptors. Hum Reprod 30:925-36 (2015). PubMed: 25662808
  • Ghaemimanesh F  et al. Production and Characterization of a Novel Monoclonal Antibody Against Human Sortilin. Monoclon Antib Immunodiagn Immunother 34:390-5 (2015). PubMed: 26683178
  • Ezkurdia N  et al. Inhibition of neuronal apoptosis and axonal regression ameliorates sympathetic atrophy and hemodynamic alterations in portal hypertensive rats. PLoS One 9:e84374 (2014). WB . PubMed: 24400086
  • Campagnolo L  et al. Sortilin expression is essential for pro-nerve growth factor-induced apoptosis of rat vascular smooth muscle cells. PLoS One 9:e84969 (2014). IF, ICC . PubMed: 24404198
  • Tsika E  et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet N/A:N/A (2014). PubMed: 24740878
  • Li J  et al. Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice. J Biol Chem 289:22437-49 (2014). WB ; Mouse . PubMed: 24986865
  • Mbikay M  et al. Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture. FEBS Open Bio 4:755-62 (2014). PubMed: 25349780
  • Klingenberg R  et al. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123:1323-34 (2013). WB ; Mouse . PubMed: 23426179
  • Bi L  et al. Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. J Lipid Res 54:2754-62 (2013). Mouse . PubMed: 23904453
  • De Muynck L  et al. The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding. Neurobiol Aging 34:2541-7 (2013). IP ; Zebrafish . PubMed: 23706646
  • Lee WC  et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet N/A:N/A (2013). WB, ICC/IF ; Human . PubMed: 24163244
  • Mufson EJ  et al. Hippocampal proNGF signaling pathways and ß-amyloid levels in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol 71:1018-29 (2012). PubMed: 23095849
  • Prabakaran T  et al. Mannose 6-phosphate receptor and sortilin mediated endocytosis of a-galactosidase A in kidney endothelial cells. PLoS One 7:e39975 (2012). PubMed: 22768187
  • Strong A  et al. Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest 122:2807-16 (2012). PubMed: 22751103
  • Prabakaran T  et al. Receptor-mediated endocytosis of a-galactosidase A in human podocytes in Fabry disease. PLoS One 6:e25065 (2011). PubMed: 21949853
  • Terry AV  et al. Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. Physiol Behav 102:149-57 (2011). WB ; Rat . PubMed: 21059364
  • Yang M  et al. Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing. J Biol Chem 286:16272-84 (2011). IP ; Human, Rat . PubMed: 21357693
  • Bao JX  et al. Activation of membrane NADPH oxidase associated with lysosome-targeted acid sphingomyelinase in coronary endothelial cells. Antioxid Redox Signal 12:703-12 (2010). Flow Cyt ; Cow . PubMed: 19761405
  • Jedrychowski MP  et al. Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem 285:104-14 (2010). WB ; Mouse, Rat . PubMed: 19864425
  • Wu LL  et al. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem 285:5614-23 (2010). WB ; Human . PubMed: 19996106
  • Kiss M  et al. Sortilin is expressed in cultured human keratinocytes and is regulated by cutaneous neuropeptides. J Invest Dermatol 130:2553-60 (2010). WB, IHC ; Human . PubMed: 20613775
  • Hu F  et al. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron 68:654-67 (2010). PubMed: 21092856
  • Fan YJ  et al. Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats. Eur J Neurosci 27:2380-90 (2008). PubMed: 18430030
  • Nelson TJ & Alkon DL Protection against beta-amyloid-induced apoptosis by peptides interacting with beta-amyloid. J Biol Chem 282:31238-49 (2007). WB ; Rat . PubMed: 17761669
  • Sánchez E  et al. SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor. ASN Neuro 7:N/A (0). WB . PubMed: 26297037

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