Sotrastaurin, pan-PKC inhibitor (ab219867)
Key features and details
- Potent, selective pan-PKC inhibitor
- CAS Number: 425637-18-9
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sotrastaurin, pan-PKC inhibitor -
Description
Potent, selective pan-PKC inhibitor -
Alternative names
- 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
- AEB071
- NVP-AEB071
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Biological description
Potent, selective pan-PKC inhibitor (Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay). Prevents the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. Displays potential immunosuppressive activity.
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CAS Number
425637-18-9 -
Chemical structure
Properties
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Molecular weight
438.48 -
Molecular formula
C25H22N6O2 -
PubChem identifier
10296883 -
Storage instructions
Store at -20°C. Store under desiccating conditions. -
SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab219867 has not yet been referenced specifically in any publications.
