Key features and details
- Potent, selective pan-PKC inhibitor
- CAS Number: 425637-18-9
- Form / State: Solid
- Source: Synthetic
Product nameSotrastaurin, pan-PKC inhibitor
DescriptionPotent, selective pan-PKC inhibitor
Potent, selective pan-PKC inhibitor (Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay). Prevents the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. Displays potential immunosuppressive activity.
Storage instructionsStore at -20°C. Store under desiccating conditions.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab219867 has not yet been referenced specifically in any publications.